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Application of Chemiluminescence in Pharmaceutical,metal Ion and Amino Acid Analytisis

Author: XuShuJing
Tutor: ChenXiaoLan
School: Xiangtan University
Course: Analytical Chemistry
Keywords: Chemiluminescence Pharmaceutical Analysis Metal ion Amino acids
CLC: O657.3
Type: Master's thesis
Year: 2010
Downloads: 118
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Abstract


Chemiluminescence refers to the chemical energy generated in a chemical reaction process, the molecules absorb the reaction freed excited state substance, issued when the return to the ground state of the optical radiation known as chemiluminescence, the use of this phenomenon analysis method called chemical Chemiluminescence. Chemiluminescence method with Flow Injection can improve the precision of the analysis, the simple operation, fast analysis, thereby expanding chemiluminescence trace and analysis of the application of semi-trace substances. This thesis mainly flow injection chemiluminescence analysis in drugs, metal ions and amino acid analysis. The main contents are as follows: (1) in an alkaline medium, the potassium ferricyanide oxidation of luminol chemiluminescence cephradine significant enhancement of the system. Based on this combination of flow injection chemiluminescence method for the determination of cephradine content. The linear range for of 4.58 × -7 of 4.58 × -4 mol / L, the detection limit of 8.01 × 10 -8 mol / L; 11 -4 mol / L, 2.29 × 10 cephradine parallel measurements, the relative standard deviation of 0.99%. Act cephradine capsules content were measured to obtain satisfactory results. (2) under alkaline conditions, L-aspartic acid of luminol - potassium permanganate reaction chemiluminescence have a significant enhancing effect. Various factors that affect the flow injection chemiluminescence experimental results show that L-aspartic acid under optimized conditions the 1.0 x 10-6 mol / L 1.0 × 10 - 3 mol / L concentration range of luminous intensity and concentration showed a good linear relationship between the detection limit (3σ) for of 4.6 × -7 mol / L concentration of 1.0 × 10 -5 mol / L of L-aspartic acid for 11 determinations, relative standard deviation (RSD) was 1.38%. Of L-aspartic acid were measured in synthetic samples, recoveries between 97.5% 105.0%. (3) tri-sodium citrate stabilizer directly in aqueous solution of CdS quantum dots, and examine the nature of the fluorescence quantum dot size chemiluminescence CdS quantum dots can be greatly enhanced Luminol - high manganese potassium chemiluminescence system luminous intensity, while the Cu 2 strongly inhibited CdS-luminol luminescence signal - potassium permanganate system, pursuant to which the establishment of a CdS-Luminol - high manganese potassium chemiluminescence determination of Cu 2 analysis method. In the optimal experimental conditions, the relative chemiluminescence intensity of the system with Cu 2 concentration showed a linear relationship, the linear range of 1.0 × 10 -10 mol / L 1.0 × 10 -7 mol / L, the detection limit of 3.77 × 10 -11 mol / L. The method is sensitive, heavy linear for the detection of copper ion content in the tap water, and be satisfied with the results of the chemiluminescence reaction mechanism was discussed.

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CLC: > Mathematical sciences and chemical > Chemistry > Analytical Chemistry > Instrument analysis ( physics and physical chemistry ) > Photochemical analysis ( spectral analysis method)
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