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Analytical Applications of Chemiluminescence in Metal Ion and Pharmaceuticals Analysis

Author: PanZuo
Tutor: HuangYuMing
School: Southwest China Normal
Course: Analytical Chemistry
Keywords: Chemiluminescence Flow injection analysis Metal ion analysis Pharmaceutical analysis
CLC: TQ460.7
Type: Master's thesis
Year: 2005
Downloads: 112
Quote: 1
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Abstract


Flow injection (FI) chemiluminescence (CL) analysis has made great progresses in analytical chemistry for its high sensitivity with a wide linear range, simple instruments, rapidity and reproducibility in signal detection, and being appropriate for on-line analysis. Chemiluminescence is defined as the emission of light emission from an electronically excited state species which is produced during the course of a chemical reaction, and is observed when an electronically excited product or intermediate formed during a chemical reaction decays to the ground state by emitting a photon. The method which confirms the composition content according the CL intensity or gross CL quantity at a certain time is called the chemiluminescence analysis.This paper includes two parts: Part one is a review of chemiluminescence. In this section, the phylogeny of chemiluminescence is presented simply and the applications of chemiluminescence in metal ions and pharmaceutical analysis are summarized. Part two is a study report. It deals with the following systems according as the principle of chemiluminescence: 1) KMnO4-luminol-aluminium (III) ; 2) KMnCvHCHO-phentolamine system; 3) Determination of resveratrol by CL with potassium permanaganate and formaldehyde; 4) Determination of resveratrol by CL with potassium ferricyanide and luminol. 1. KMnO4- Luminol System for the Determination of AluminumA novel, simple and sensitive method for the determination of trace aluminum with no samplepretreatment is developed in this study, based on the distinct inhibition to chemiluminescence (CL) from luminol-KMnO4 reaction. Compared to other publications in the literature, this method has the merits of more rapidity and more simplicity due to no sample pretreatment needed. Furthermore, this paper discusses the effect of luminol pH on the kinetic curves in the presence of Al(III). Under optimized conditions, the limit of detection for Al(III) was 2.0μg l~1 (3a) and the calibration curve from 8.0μg l~1 to 500μg l~1 was linear (r=0.9903,n=9), with a relative standard deviation (RSD) of 3.6% at the 100μg l~1 of Al level (n=11). It was available for the determination of trace Al in both tap waters and bottled mineral waters, and the results were in good agreement with those detected by fluorescence and atomic absorption spectrometry methods.2. Potassium Permanganate-Formaldehyde-Phentolamine SystemA new chemiluminescent method was proposed for the determination of phentolamine, which was based on enhancement effect of formaldehyde on the weak chemiluminescence produced by the permanganate oxidation on phentolamine in acidic media. In optimum conditions, the proposed method allowed the determination of phentolamine in the range 0.01 -5.0 μg/mL , with a detection limit of 5 ng/mL. The relative standard deviation was 4.0% (n=l 1) for 0.5 μg/mL phentolamine, and the method has been applied, with satisfactory result to determine phentolamine in commercial preparations and biological fluids. On the basis of investigations of chemiluminescent, fluorescent and ultraviolet spectra of phetolamine in acidic solution containing potassium permanganate and formaldehyde, a possible mechanism for this reaction was proposed.3. Determination of Resveratrol by Chemiluminescence with Potassium Permanaganate and FormaldehydeA new chemiluminescent method was proposed for the determination of resveratrol, which was based on enhancement effect of formaldehyde on the weak chemiluminescence produced by

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