Dissertation > Excellent graduate degree dissertation topics show

Experimental Study of Influence of Atrovastatin on Expression of NF-κB in Retionpathy of Diabetic Rats

Author: WeiWei
Tutor: WangXiaoMei
School: Zunyi Medical College,
Course: Internal Medicine
Keywords: Atovastatin Diabetes retinopathy NF-κB
CLC: R587.1
Type: Master's thesis
Year: 2011
Downloads: 2
Quote: 0
Read: Download Dissertation

Abstract


Objective:To explore the effects and mechanism of atrovastatin on expression of the NF-κB on retionpathy of diabetic rats.Methods:A total of 42 male SD rats were randomly taken out 28 to make diabetes model by induced injection of 65mg streptozotocin (STZ)into enterocoelia,the rest was normal control group.After the model maded, atrovastatin(2mg/kg/d) were given the treated group,and normal control group and diabetic rats without treatment group was given equivalent water.After 3 and 6 months.the rats were killed.Isolated total RNA of the retina from one eye for each rat,and the other eye was prepared for the examination of immunohistochemistry. Determinated the NF-κB mRNA expression amoug three groups by the method of RT-PCR. Observed the distribution of the NF-κB in the retina, and compared the diference of three group.Results:PCR shows that NF-κB mRNA was increased in the retina of diabetic compared with control rats (P<0.05). Drugs treated animal showed significiantly decreased leveals of NF-κB mRNA in the retina compared with the untreated diabetic group (P< 0.05).IHC shows that there existed positive cells in the vascular layer.The increased number of the specific dyed cells in the diabetic retina also showed darer color (P<0.05).Additionaly,the drug treated retina trended to have fewer positive cells and lighter color compared with diabetic ones (P<0.05)Conclusion:Atovastatin can down-regulate the expression of NF-κB and suppress the increased levelof NF-κB protein in the retina of diabetic rats,slow the progress of retinopathy.

Related Dissertations

  1. The Effects of PCV2 on NF-κB Signal in Piglet’s Lymphocytes in Vitro,S858.28
  2. Nuclear Dot Protein NDP52 Bind to Tumor Necrosis Factor Receptor Associated Factor 6 and Their Clinical Significance of Research,R363
  3. Effective of the Interaction between NDP52 and TRAF6 and TRAFs on NF-κB Signal Pathway,R363
  4. The Molecular Mechanism Intervention of Selenium on the Learning and Memory Injury by Drinking Water Fluorosis,R599
  5. The Effect and Mechanism of p38MAPK Inhibitor CBS3830 on Intimal Hyperplasia in Autogenous Vein Grafts of Diabetic Rats,R587.1
  6. Effects of Partial Hepatic Ischemia/Reperfusion Injury on Postoperative Cognitive Function in Mice,R614
  7. The Expression and Mechanism of NF-κ B and IL-6 after 90% Portal Vein Ligation in Rats,R657.3
  8. The Sequence Analysis of RNA Components from Lactobacillus Metabolites and Parts of the Biological Function,R378
  9. Study on Therapy and Mechanisms of the Role of Tang Kang in Diabetic Rat and Endothelial Cells,R285.5
  10. Effects of Hypothermia Resuscitation on PPAR-γ and Related Gene Expression in Rats Lung during Hemorrhagic Shock,R605.971
  11. The Research of Nf-kB、TNF-a and PLGF in the Pathogenesis and Severity of Preeclampsia and Theirs Relevance,R714.244
  12. Influence on NF-κB P65 and ASPP2 of Murine Lewis Lung Cancer of NF-кB Inhibitor PDTC and Cisplatin,R734.2
  13. Restructuring Agkistrodon disintegrin Adinbitor human non-small cell lung cancer cell line A549,R285.5
  14. NF-κB inhibitor PDTC on non-small cell lung cancer cells and JNK protein expression iASPP impact,R734.2
  15. Danxingtongluo decoction on cerebral ischemia-reperfusion injury in TNF-α, NF-κB expression,R285.5
  16. Effects of Propofol on the Apoptosis and Activation of NF-κB in Polymorphonuclear Neutrophil in Acute Lung Injury Induced by LPS in Rats,R965
  17. The Influence of Ambroxol and Varenicline Tartrate on Expression of TGF-β1 and IκBα in Rats with Chronic Bronchitis Induced by Smoking,R562.21
  18. Effect of P120ctn on NF-κB Signaling Pathway in Airway Inflammatory Responses Induced by Formaldehyde,R114
  19. The Regulation and Research of Mechanism of "Plus Sijunzi Decoction" in Immune System of the Aging Rat,R285.5
  20. 1. TmTNF-α-mediated Apoptotic Signaling Via TNFR2 2. Antibody Preparation and Identification,R392

CLC: > Medicine, health > Internal Medicine > Endocrine diseases and metabolic diseases > Islet disease > Diabetes
© 2012 www.DissertationTopic.Net  Mobile