Dissertation > Excellent graduate degree dissertation topics show

Preoperative lung cancer patients in clinical studies of hyperbaric oxygen therapy

Author: ZhuRuiKai
Tutor: YuanTianZhu
School: Guangxi Medical University
Course: Cardiothoracic Surgery
Keywords: Hyperbaric oxygen Lung Cancer Rheology Surgical complications Clinical Research
CLC: R734.2
Type: Master's thesis
Year: 2011
Downloads: 11
Quote: 0
Read: Download Dissertation

Abstract


Objective: to have lung cancer after complete resection of non-small cell lung cancer indications (nonsmall-cell lung cancer, NSCLC) in patients with preoperative hyperbaric oxygen (hyperbaric oxygen, HBO) therapy, by detecting whole blood reduced viscosity (high, medium, low-cut), peripheral arterial oxygen saturation (saturation of arterial blood oxygen, Sa0 2 ), arterial oxygen tension around (arterial oxygen partial pressure, Pa0 2 ) explore the preoperative HBO therapy in the perioperative period are likely to improve patient body tissue oxygen supply and whether they may reduce the patient's blood viscosity, is conducive to postoperative recovery, and to observe postoperative hospital stay, postoperative complication rate, expected comprehensive treatment of NSCLC provide a new method. Methods: November 2009 to December 2010 Fourth Affiliated Hospital of Guangxi Medical University complete resection of lung cancer, 42 patients with NSCLC were randomly divided into experimental group and control group 21 cases. The control group underwent routine preoperative and postoperative therapy; experimental group on the basis of conventional therapy before surgery I HBO treatment (treatment day 1, continuous 5d, the treatment pressure is 0.2Mpa, Section 6d surgery). HBO treatment 1d, the two groups before surgery 1d, 3d, respectively, after the first measurement Sa0 2 and Pa0 2 , whole blood reduced viscosity (high, medium and low-cut), Comparison between groups each index corresponding time whether there were significant differences (α = 0.05 to test the level), while comparing postoperative hospital stay, postoperative morbidity without significant difference (α = 0.05 to test the level ). Results: (1) the experimental group and the control group before HBO treatment preoperative PaO 2 , SaO 2 , whole blood reduced viscosity (high, medium and low-cut) showed no statistical significance (P gt; 0.05), comparable. (2) the experimental group after HBO treatment (ie, 1 day before surgery) detection index and the control group compared preoperative detection index, the former PaO 2 was significantly higher than that of the latter PaO 2 (t = 2.993, P lt; 0.05), the former SaO 2 and the latter SaO 2 difference was not statistically significant (t = 1. 392, P gt; 0.05); whole blood reduced viscosity of the experimental group was significantly lower than the control group, whole blood reduced viscosity (t high = -8.592, P high lt; 0.05; t in = -7.557, P in lt; 0.05; t low = -4.922, P low lt; 0.05). (3) the experimental group one day before surgery the PaO 2 , SaO 2 HBO treatment was significantly higher than before the PaO 2 , SaO 2 (P lt; 0.05). (4) the experimental group after HBO treatment (ie, 1 day before surgery) of whole blood reduced viscosity was significantly lower than before treatment HBO whole blood reduced viscosity (t high = 6.628, P high lt; 0.05; t in = 6.398, P in lt; 0.05; t low = 7.492, P low lt; 0.05). (5) the third postoperative day, the experimental group PaO 2 was significantly higher PaO 2 (t = 3.263, P lt; 0.05), the experimental group SaO 2 and the control group SaO 2 no significant difference (t = 1.396, P gt; 0.05); whole blood reduced viscosity of the experimental group was significantly lower than the control group, whole blood reduced viscosity (t high = -5.322, P high lt; 0.05; t in = -4.695, P in lt; 0.05 ; t low = -3.191, P low lt; 0.05). (6) the experimental group postoperative hospital stay (mean 12.62 ± 3.99d) than the control group, postoperative hospital stay (mean 13.33 ± 4.64d) shorter, but the difference was not statistically significant (t = -0.535, P gt; 0.05) ; experimental group, incidence of postoperative complications (14.3%) than the control group incidence of postoperative complications (23.8%) was slightly lower, but the difference was not statistically significant (X 2 = 0.154, P gt ; 0.05). Conclusion: NSCLC patients with preoperative HBO treatment: ① the potential to improve preoperative pulmonary function, surgery may improve patient tolerability and reduce the risk of surgery. ② may reduce blood viscosity (whole blood reduced viscosity), in theory, could prevent or delay the metastatic NSCLC. ③ have shorter postoperative hospital stay and reduce surgical complication rate trend.

Related Dissertations

  1. Chen Shu- long academic thinking clinical research and clinical experience and the treatment of spleen dampness Huoxuetongmai method of PTS,R249
  2. Go through the academic ideas and a summary of clinical experience and three sons and four cents decoction children cold to relying stagnation cough clinical research,R249.2
  3. The Clinical Research for the Effect of Iodine-125 Seeds Implanted in Advanced Bronchial Lung Cancer,R734.2
  4. Study on Rheological Properties of Rabbit Skeletal Myosin under Different Conditions,TS251.1
  5. Wang Huanlu teacher academic thinking and Vision Bi Tong Luo Tang heat treatment of Blockage -type rheumatoid arthritis clinical research and clinical experience,R259
  6. Effects of 5-Aza-2-deoxycytidine on DNA Methylation and Expression of p16 and MGMT Gene in Lung Cancer Cell Line SPC-A-1,R734.2
  7. Methylation of p16 Gene in Plasma and Tissues from Non-small Cell Lung Cancer Patients, Demethylation and the Biological Behavior of Lung Cancer Cell and Transcription of p16 Gene,R734.2
  8. The Clinical Value of Detection of Serum TPS, CEA, CYFRA21-1, NSE for Diagnosis in Patients with Lung Cancer,R734.2
  9. Thickness of Endometrium on Different Chinese Medicine Symptom of Hypomenorrhea,R737.33
  10. Study on the Expression and Correlation of Metallothionein and Matrix Metalloproteinase-2 in Non-small Cell Lung Cancer,R734.2
  11. The Effect of RNA Interference-mediated ERCC1 Gene on the Chemo-treatment Sensitivity of NSCLC in Vitro,R734.2
  12. Non-small Cell Lung Cancer Analysis of 133 Cases of CVATS Lobectomy,R734.2
  13. Clinical Observation of Pemetrexed for Treating Advanced Non-small Cell Lung Cancer,R734.2
  14. Combined Detection of Tumor Markers in the Diagnosis and Treatment of Lung Cancer to Determine the Clinical Significance,R734.2
  15. Exploreing the Mechanism of Xieshifeiaifang Ii on Treating Lung Cancer with Pleura Effusion,R734.2
  16. The Early-stage Clinical Research of Preservation of the Femoral Neck in Total Hip Arthroplasty,R687.4
  17. The Analysis of the M8000/3 Coder of the Lung Cancer Case in a Hospital Between 2006 to 2010,R734.2
  18. Expression of Chemokine Receptor CCR5 in Human Non-small-cell Lung Cancer,R734.2
  19. Influences of Cisplatin on Expressions of P-glycoprotein in the Resistance Cells of in Lung Cancer Xenografts in the Mice,R734.2
  20. Clinical Research on Detecing of the Combined Survivin mRNA with Cytokeratin 19(ck19) mRNA in Peripheral Blood of Non-small Cell Lung Cancer,R734.2
  21. The in Vitro Study of Serum-free Culture Combined DDP Enriching Human Lung Cancer Stem Cells,R734.2

CLC: > Medicine, health > Oncology > Respiratory system tumors > Lung tumors
© 2012 www.DissertationTopic.Net  Mobile