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Background: Children with recurrent abdominal pain (recurreut abdominal pain, RAP) clinical common, particularly in the functional common, functional abdominal pain is one of functional somatic symptoms, refers to any organic disease can not be explained by non-specific heterosexual somatic symptoms, can not be fully explained by the medical knowledge, or the severity of their symptoms and medical examination does not match. Clinicians often feel such cases difficult to carry out some unnecessary laboratory examinations, increased spiritual, economic burden. Children often given to antispasmodic agents, probiotics and other long-term conventional treatment, poor efficacy, which led to parents and children with mental anxiety and affect normal life and learning in children. In recent years, functional recurrent abdominal pain pediatrician has caused a lot of concern, the data reported show functional abdominal pain on children may be involved in the etiology personality, mood disorders (anxiety, depression), physiological and environmental, gastrointestinal hormones (MTL, SP ) secretion disorders and other factors interact. Objective: ① To investigate children with functional recurrent abdominal pain in plasma motilin (MTL), P substance (SP) levels and the disease. ② while functional recurrent abdominal pain in children and healthy children for self-rating depression scale (SDS) and Self-Rating Anxiety Scale (SAS) questionnaire, to explore anxiety and depression disorders and functional recurrent abdominal pain relevance, and the impact of the disease. Method: ① using radioimmunoassay analysis method in 50 cases of recurrent abdominal pain in children (study group) and 30 healthy children (control group), fasting plasma MTL, SP measured. ② and take measurements SDS and SAS tables psychological factors tested. Results: ① functional recurrent abdominal pain in children with plasma MTL was 273.31 ± 16.38 pg / ml, SP was 52.92 ± 12.29pg/ml; MTL control group was 225.46 ± 16.56pg/ml, SP was 33.14 ± 8.15 pg / ml . Functional recurrent abdominal pain in children with plasma MTL, SP content compared with the control group mean increased significantly (P lt; 0.05). ② functional group of children with recurrent abdominal pain SAS average score of 54.37 ± 9.56, significantly higher than those who are asymptomatic, there are differences in change (P lt; 0.05). SDS average score of 55.42 ± 10.31, compared with the asymptomatic group differences in change (P lt; 0.05). Conclusion: ① functional in vivo in children with recurrent abdominal pain exist MTL, SP secretion disorder and anxiety, depression, mood disorders, indicating that children with functional recurrent abdominal pain may be associated with MTL, SP levels increased and mood disorders are closely related. ② clinically by MTL, SP analogues, blockers and psychological counseling to the diagnosis and treatment of functional recurrent abdominal pain, to relieve symptoms in children and psychological stress.
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