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Objective: To observe the different concentration of medical ozone and sodium hyaluronate knee articular injection of the treatment of elderly patients with unilateral knee osteoarthritis clinical effect. : Union Hospital in Wuhan City, Hubei Province, Zhongshan Hospital outpatient select from August 2009 to June 2010 in line with the standard of unilateral knee osteoarthritis patients with a total of 114 cases were randomly divided into four groups were randomly divided into four groups namely A , B, C, D group. A group of ozone therapy group (26 cases): ozone concentration 40ug/ml; the B group ozone treatment group (28 cases): ozone concentration 30ug/ml; the C group ozone treatment group, 28 cases: ozone concentration 20ug/ml, samples were taken from 20 ml of ozone injected Intra-articular, twice a week for a course of treatment. D group of 32 patients: intra-articular injection of sodium hyaluronate (2.5ml/25mg) injection, once a week, five times as a course of treatment. VAS score, JOA efficacy score, the WOMAC osteoarthritis index score, as well as BBS rating scale to assess the two sets of medication after one week in January, March, June, changed the situation and side effects, and do statistical analysis. Results: Before treatment (T0) four groups of patients the VAS, JOA efficacy, the WOMAC arthritis index, and BBS balance scale score differences without statistical significance (P gt; 0.05). After treatment VAS score four groups each time period, JOA efficacy score, WOMAC Osteoarthritis Index and BBS Balance Scale scores were better than before treatment, the difference was statistically significant (P lt; 0.05). Four sets of various ratings in the three months VAS and WOMAC Osteoarthritis Index decreased compared with the previous point in time, the difference was statistically significant (P lt; 0.05); the JOA efficacy ratings and BBS balanced scale score compared with the previous point in time The higher, the difference was statistically significant (P lt; 0.05). T1 and T2 time points A, B group, VAS scores and JOA efficacy ratings were better in the C and D group, the difference was statistically significant (P lt; 0.05), B group VAS and JOA efficacy scores were better than the A group, the difference was statistically significant (P lt; 0.05). T3 time points A, B, D group, VAS scores and JOA efficacy ratings were better in group C, the difference was statistically significant (P lt; 0.05), Group D of the T4 time point VAS score and the JOA efficacy square better than A, B, C group, the difference was statistically significant (P lt; 0.05). T1 point-in-time Group D WOMAC osteoarthritis index higher than A, B, C group, T3 Group C WOMAC osteoarthritis index higher than A, B, D group. Four groups of patients six months after treatment (T4) VAS score, the WOMAC Osteoarthritis Index score after treatment, compared to the three months (T3), rated somewhat higher, the difference was statistically significant (P lt; 0.05) compared with the preoperative still reduce, the difference was statistically significant (P lt; 0.05); compared the JOA the efficacy score, BBS Balance Scale score compared with March, has decreased, the difference was statistically significant (P lt ; 0.05), compared with the preoperative still higher statistically significant difference (P lt; 0.05). Group D local infection and swelling and pain in a total of seven cases. Conclusion: Different concentrations of medical ozone and sodium hyaluronate group can reduce pain and improve knee function to improve the quality of life and have a certain effect on the prevention of falls. Concentration 30ug/ml ozone three months before the clinical effects and side effects of evaluation in the the other ozone treatment group and the sodium hyaluronate group, six months of knee articular injection of sodium hyaluronate efficacy in ozone therapy group, but medical ozone group rapid onset of effect is obvious, and the security is good, is worth promoting treatment of knee osteoarthritis a good way.
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