Dissertation > Excellent graduate degree dissertation topics show

Study on the Copper-Catalyzed Replacement of Bromine by Fluorine and Chlorine in Aromatic Compounds

Author: HanYanLei
Tutor: FengXiuJuan
School: Dalian University of Technology
Course: Fine Chemicals
Keywords: Copper catalyst Bromides Fluoroalkyl reaction Chlorination reaction
CLC: O643.32
Type: Master's thesis
Year: 2011
Downloads: 77
Quote: 0
Read: Download Dissertation

Abstract


Fluorinated aromatic and chlorinated aromatic hydrocarbons is an important chemical intermediates, widely used in the synthesis of pharmaceuticals, pesticides , as well as functional dyes , the radioactive 18F labeled organic or positron emission tomography technology commonly used tracer . Conventional fluorination method typically requires relatively harsh reaction conditions , the functional group compatibility Poor ; the traditional chlorination method exists differential selectivity of the reaction , the electron-deficient substrates difficult Chloride , inconvenient operation and other shortcomings . This article uses inexpensive and environmentally friendly copper as a catalyst , respectively bromine on the aromatic ring the fluorinated reaction and chlorinated reaction in-depth exploration and research , and the successful realization of efficient chlorinated aromatic ring bromine under mild conditions . Fluorinated reaction Bromoacetophenone as a model reaction , from the source of fluorine , catalysts , ligands, solvent and phase transfer catalyst five aspects of fluorinated reaction were discussed , but ultimately failed to achieve fluorinated the smooth progress of the reaction , we hypothesized that is not designed to meet the reductive elimination ligand . 2 the use of cuprous oxide as the catalyst , L - proline as the ligand , under 110 ° C , the model substrate bromo- toluene and tetramethyl ammonium chloride in an ethanol solvent in a chlorinated reaction , to a yield of 98% rate generates chlorotoluene . Expand under the reaction conditions , the reaction substrate , bromo include heterocyclic and fused ring aromatic hydrocarbons can be a high yield of conversion into the corresponding chlorinated product yield is between 81-99 % . The first time we realized chlorinated efficient copper -catalyzed aromatic ring bromine . The chlorinated reaction with mild reaction conditions, functional group compatibility , and a wide range of substrates , green , provides a new method for the synthesis of some complex structure with special functions chlorinated aromatic ring compounds , is now chloride method as an important complement .

Related Dissertations

  1. Studies on the Synthesis of Ferrocenyl Derivatives under Ultrasound Irradiation,O627.81
  2. Study on Preparation and Catalytic Performance of Activated Carbon Supported Copper Catalysts,O643.36
  3. Studies of Aryne Involved Reactions,O621.25
  4. Study on Preparation and Application of Chlorinated Polymer,O631.3
  5. Preparation and Characterization of spiral fibers,TQ340.1
  6. For C-N bond-forming reaction in some studies,O643.32
  7. Study on Preparation and Catalytic Performance of CuⅠ/SO42-/MxOy and CuⅠ/S2O82-/MxOy Catalysts,O643.36
  8. The Preparation of Highly Active Aminated Modified Resin Supported Palladium Complexes and Their Catalytic Activity for Heck Reaction,O643.3
  9. The Direct Synthesis of Triethoxysilane and the Application for Hydrosilylation Reaction of Alkenes,O621.2
  10. Study on the Catalytic Characters of Colloidal Copper Catalysts and Theoretical Calculations,O643.32
  11. Synthesis of Fluoropyridazinone,TQ253
  12. Catalysts with High Activities at Low Temperature for the Hydrogenolysis of Methyl Formate,TQ223.1
  13. Oxidation of Alcohols Utilizing Oxone as Oxidant Catalyzed by Metal-catalysts,O643.32
  14. Study on Copper Catalyzed C-S Coupling Reaction and Synthesis of Sulfur Heterocyclic Compounds,O643.32
  15. Synthesis of substrate France nano copper particles of carbon fiber array,TB383.1
  16. Studies on Copper(Ⅱ)-Catalyzed C-H Functionalization,O621.25
  17. The Study of Suzuki Coupling Reaction in Aqueous Media and Copper-Catalyzed Reaction of Arynes,O643.32
  18. Ferrocenyl imidazoline palladium Synthesis and catalytic reaction .,O643.32
  19. Cyclopropanation of Alkenes on Heterogeneous Catalysts,O643.3
  20. Copper -catalyzed cross-coupling reaction,O643.32

CLC: > Mathematical sciences and chemical > Chemistry > Physical Chemistry ( theoretical chemistry ),chemical physics > Chemical kinetics,catalysis > Catalytic > Catalytic reaction
© 2012 www.DissertationTopic.Net  Mobile