Dissertation > Excellent graduate degree dissertation topics show

Effect of Removal of One Side of Condylar to the Opposite Side on Cell Proliferation and Cell Apoptosis

Author: LiaoLiFan
Tutor: LuoYingWei;LiSong
School: Kunming Medical College
Course: Stomatology
Keywords: condylectomy cartilage cell proliferation apoptosis
CLC: R782.6
Type: Master's thesis
Year: 2011
Downloads: 18
Quote: 0
Read: Download Dissertation

Abstract


[Objective] To investigate the effect of the removal of one side of the condylar to the opposite side on cell proliferation and cell apoptosis.[Method] Thirty-six 5~6 months old Japanese big-ear rabbits were randomly divided into 3 groups:the blank control group、the sham-operated group and the operation group.The opetation group was created by removing the right condylar. The sham-operated group was create by the same way except not dissecting one side of their condylars. The left condylar (the nonoperative side) cartilages of every group were dissected in 2 months、4 months after the operation accordingly. HE staining was used to observe the histologic changes of the condylar cartilage;Immunohistochemical staining was used to qualitively examine the PCNA positive cell;TUNEL was chosen to detect the apoptotic cell.[Result] HE staining showed that,among the 3 group,from 2 months after the operation to 4 months after the operation, bone trabecula of subchondral bone was thickening;marrow cavity was broadening.At the same time-points,there is no difference beween blank control group and sham-operated group in HE staining;But compared with the blank control group and sham-operated group at the same time-points, among the operation groups, cells were arranged disorder; bone trabecula of subchondral bone was thinning; and these changes of 4 months after the operation was more significant than those of 2 months after the operation. Immunohistochemical staining and TUNEL showed that,compared with the blank control group and sham-operated group at the same time-points,the number of the PCNA positive cells decreased significantly in both 2 months and 4 months operation group; while the number of TUNEL positive cells increased significantly in both 2 months and 4 months operate group(P< 0.05). Compared with the operation group in 2 months after the operation, the number of the PCNA positive cells decreased significantly in the operation group in 4 months after the operation;while the number of TUNEL positive cells increased significantly (P<0.05)[Conclusion] Unilateral condylectomy will decrese the proliferation capacity and increase apoptosis of the opposite condylar,and these effects aggravated as time went on.

Related Dissertations

  1. The Study on Cryopreservation and Mechanism of Freezing Injury on the Spermatozoa of Coelomactra Antiquate,S968.3
  2. The Anti-tumor Effect of CADPE and Inducing Apoptosis in Human Gastric Cancer Cells,R735.2
  3. Cloth and β- elemene combined administration of anti-tumor effect and mechanism of celecoxib,R96
  4. TRAIL in the regulation of tumor invasion CD4 ~ CD25 ~ Treg,R730.2
  5. The Study of Lead Exposure on Cyprinus Carpio Ovary Epithelial Cells,X174
  6. Effects of Diclazuril on G3PDH in Second-generation Merozoites of Eimeria Tenella,S858.31
  7. The Effects and Preliminary Study of PCV2 on Ca2+ Signal in Lymphocytes of Piglets,S858.28
  8. Effects of Angiogenic Factor on Follicular Angiogenesis and Development in Sexual Maturity Mice,S852.2
  9. Expression of β-Catenin in Pig’s Ovary and the Effect of β-Catenin on Porcine Granulosa Cells Apotosis and Steroidogenesis Related Enzyme,S828
  10. Induced Combination Apoptosis by FB1 and AFB1 in Vero Cell,S856.9
  11. The Apoptosis Mechanism Induced by Aflatoxin B1 and Deoxynivalenol in Primary Hepatocyte of Cyprinus Carpio,S856.9
  12. Effects of BMPR-IB Gene Silencing by Small Interfering RNA on Apoptosis of Porcine Pollicular Granulosa Cells and Ecpression of BMP Pathy-Way-Ralted Genes,S828
  13. The Effects of Don on Proliferation, Differentiation, and Apoptosis of Chondrocytes in Chicken,S858.31
  14. The Effect of Foxol on Apoptosis of Mouse Granule Cells,S865.13
  15. Study of Melittin on Tumor Inhibition and Part of Mechanism of Human Hepatocellular Carcinoma HepG-2 Xenograft in Nude Mice,R735.7
  16. The Construction and Evaluation of a Novel Non-viral Gene Transfection System and Its Application in Mesenchymal Stem Cells Gene Recombination,R346
  17. The Protective Effect of Rat Myocardial Ischemia/reperfusion Injury Following Bone Marrow Mesenchymal Stem Cell Pretransplantation for 1 Week,R542.22
  18. Expression of WW Domain Containing Oxidoreductase Gene in Cholangiocarcinoma and Its Effect on the Biological Behavior of Cancer Cell Line QBC939,R735.8
  19. The Effects of (180F-FDG on the Apoptosis of Eca-109 Esophageal Cancer Cell Line,R735.1
  20. The Signal Mechanism Underlying DON Induced Apoptosis in BHK-21 Cells,S856.9
  21. The Expression and Mechanism of NF-κ B and IL-6 after 90% Portal Vein Ligation in Rats,R657.3

CLC: > Medicine, health > Oral Sciences > Oral and maxillofacial surgery > Temporomandibular joint disorders
© 2012 www.DissertationTopic.Net  Mobile