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Effect of Removal of One Side of Condylar to the Opposite Side on Cell Proliferation and Cell Apoptosis

Author: LiaoLiFan
Tutor: LuoYingWei;LiSong
School: Kunming Medical College
Course: Stomatology
Keywords: condylectomy cartilage cell proliferation apoptosis
CLC: R782.6
Type: Master's thesis
Year: 2011
Downloads: 18
Quote: 0
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[Objective] To investigate the effect of the removal of one side of the condylar to the opposite side on cell proliferation and cell apoptosis.[Method] Thirty-six 5~6 months old Japanese big-ear rabbits were randomly divided into 3 groups:the blank control group、the sham-operated group and the operation group.The opetation group was created by removing the right condylar. The sham-operated group was create by the same way except not dissecting one side of their condylars. The left condylar (the nonoperative side) cartilages of every group were dissected in 2 months、4 months after the operation accordingly. HE staining was used to observe the histologic changes of the condylar cartilage;Immunohistochemical staining was used to qualitively examine the PCNA positive cell;TUNEL was chosen to detect the apoptotic cell.[Result] HE staining showed that,among the 3 group,from 2 months after the operation to 4 months after the operation, bone trabecula of subchondral bone was thickening;marrow cavity was broadening.At the same time-points,there is no difference beween blank control group and sham-operated group in HE staining;But compared with the blank control group and sham-operated group at the same time-points, among the operation groups, cells were arranged disorder; bone trabecula of subchondral bone was thinning; and these changes of 4 months after the operation was more significant than those of 2 months after the operation. Immunohistochemical staining and TUNEL showed that,compared with the blank control group and sham-operated group at the same time-points,the number of the PCNA positive cells decreased significantly in both 2 months and 4 months operation group; while the number of TUNEL positive cells increased significantly in both 2 months and 4 months operate group(P< 0.05). Compared with the operation group in 2 months after the operation, the number of the PCNA positive cells decreased significantly in the operation group in 4 months after the operation;while the number of TUNEL positive cells increased significantly (P<0.05)[Conclusion] Unilateral condylectomy will decrese the proliferation capacity and increase apoptosis of the opposite condylar,and these effects aggravated as time went on.

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