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Objective: 1) study of interleukin-1β (Interleukin-1 beta, IL-1β), interleukin -8 (Interleukin-8, IL-8), and serum amyloid A (Serum amyloidA, SAA) level before surgery expression in the surgery group, and the group of patients with healthy and atherosclerosis to do a comparative analysis; 2) evaluation of IL-1p, IL-8, forming the a different postoperative period serum expression of SAA in intracranial arterial stenosis, changes and analysis of IL-1p, IL-8, SAA three indicators correlation between; 3) postoperative angiography review of serum IL-1β, IL-8 and SAA is not restenosis group with restenosis between groups relationship. Methods: ELISA was used to detect the 30 patients with intracranial and extracranial atherosclerosis (atherosclerosis, ATS) .31 cases artery stenosis (arterial stenosis, AS) patients and 30 healthy human serum IL-1p, IL-8 and SAA levels; choose April 2008 to March 2009, a total of 31 cases in the Sichuan Provincial People's Hospital, Department of Neurology, accepted intracranial stenting intracranial arterial stenosis, preoperative, postoperative 1h, 1d, 3d, 5d, and double-contrast (surgery after June to December) serum levels of IL-1p, IL-8 and SAA levels of restenosis and vascular analysis. Results: AS group of 31 patients, 40 vessels placed 40 stents were followed up for 6-12 months. June-December after a total of six cases angiography review appeared restenosis (19.35%), 3 cases of restenosis by more than 50%, more than three cases of restenosis in 10-30%. Test results found that (1) preoperative IL-1p, IL-8 and SAA expression in the healthy group and the ATS group between the AS group difference was statistically significant (p lt; 0.01); between the ATS group and the AS group, IL -1β, IL-8, SAA expression difference was not statistically significant (p gt; 0.05). (2) stenting before and after IL-1p, IL-8 and SAA levels of single-factor variance analysis shows F values ??were 21.03,20.92,20.12, suggesting that the difference was statistically significant (p = 0.0001), postoperative 1dIL-1β IL-8 expression of SAA peak with the preoperative and postoperative 1h after operation, postoperative 5d and review the time difference between both statistically significant (p = 0.0001). (3) IL-1β and SAA expression in postoperative 1h, 1d, when the review was a significant correlation (p lt; 0.05); SAA, and IL-8 expression postoperative 1d, review significant correlation (p lt IL-1β and IL-8 expression in the preoperative and postoperative 1d, 3d and review shows a significant correlation (p lt;; 0.05); 0.05). (4) restenosis group and no restenosis group between preoperative and postoperative 1d target level differences were not statistically significant (p gt; 0.05), but after review of the two groups of patients with serum IL-8 and SAA expression The difference was statistically significant (p lt; 0.05). Conclusion: The serum IL-1P, IL-8, SAA, jointly participate in the inflammatory response of the stent, and a plurality of time periods in the postoperative showed interaction and mutual influence; preoperative IL-1p, IL-8 SAA expression may indirectly reflect the presence of atherosclerotic lesions, but can not predict whether the postoperative target vessel restenosis and stenosis; postoperative SAA's low level of sustained expression may be associated with chronic inflammation and stent restenosis occurred in close contact with IL-8 and SAA common stenting arterial intimal hyperplasia and then narrow the formation process play a role.
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