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Objective: To explore the clinical manifestations of patients with gastro- esophageal reflux disease (GERD) and evaluate the therapeutic efficacy of the laparoscopic Nissen fundoplication (LNF) for the disease.Methods: Retrospectively analyzed our database of 11 patients, who underwent LNF for GERD from November 2009 to January 2011. Of the patients, 9 cases suffered mainly from esophagus symptoms including acid reflux, heartburn, belching, food reflux, and chest pain; in the other 2 patients, the predominant manifestations are respiratory symptoms like cough, phlegm and dyspnea.Results: All the patients received LNF without conversion to laparotomy. The operation time ranged from 130 to 220 minutes with a mean of 160. 5 minutes; the patients had blood loss ranged from 10 to 130 ml with a mean of 50 ml. They were discharged from our hospital in 3 to 8 days (mean, 6.5 days) after the surgery. Afterwards, all of them achieved a follow up for 1 to 12 months (mean, 5 months); a symptoms score was then made refer to the criteria for Reflux Diagnostic Questionnaire (RDQ) Score. The score showed that the symptoms including acid reflux, heartburn, chest pain, cough, dyspnea, lump sensation in the pharynx, tight throat sensation, and hoarseness are improved significantly.Conclusion: LNF is an effective treatment for GERD with minimal invasion, high safety and quick recovery.
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