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Purpose: systemic lupus erythematosus (systemic lupus erythematosus, SLE) is an autoimmune mediated autoimmune inflammation for the outstanding performance in diffuse connective tissue disease. Hematological abnormalities are more common in the first manifestation of SLE, where thrombocytopenia is the most common early misdiagnosed as idiopathic thrombocytopenic purpura (idiopathic thrombocytopenic purpura, ITP), also known as immune thrombocytopenic purpura (immune thrombocytopenic purpura) . This study is intended to pass on to thrombocytopenia as the first manifestation of SLE patients general condition of patients with ITP, laboratory and immunological tests comparative analysis of early identification of such SLE explore ways to grasp the best timing of treatment, the protection of the important organ function, improved patient outcomes. Methods: October 1989 to February 2011 the First Hospital of Jilin University, Division of Rheumatology, 35 cases were treated with thrombocytopenia as the first manifestation of SLE patients (experimental group) were retrospectively analyzed, and the distribution of their age, thrombocytopenia due to hemorrhage and a variety of anti-nuclear antibodies, complement and immune globulin combined test results, the use of statistical software SPSS 17.0 OK two independent samples t-test and chi-square test fourfold table with a random sample of the same period 58 cases of ITP patients (control group) control study. Results: thrombocytopenia as the first manifestation of SLE occurs in women of childbearing age, their peripheral blood platelet count before treatment to reduce the level of the whole body skin scattered petechiae, ecchymosis, bleeding gums, epistaxis, prolonged menstrual cycle, the volume increased even haemorrhagic manifestations such as gastrointestinal bleeding, and treatment 7 days, 14 days were associated with ITP platelets rise similar misdiagnosed. However, the experimental group and the control group a variety of anti-nuclear antibodies, complement and immunoglobulins, and other immune-related findings contrast, among SLE patients ESR (42.44 ± 27.03), C3 (0.629 ± 0.344), C4 (0.112 ± 0.936), antinuclear antibody positive rate series in ANA (73.9%), ds-DNA (21.8%), nRNP / Sm (13.0%), SSA (39.1%) compared with ITP and other test results were significantly abnormal (P lt; 0.05). CONCLUSIONS: SLE often thrombocytopenia as its first manifestation, can be after a few months, or even years after the emergence of typical manifestation of SLE clinical easily misdiagnosis, should arouse the attention of clinicians, for the performance of pure thrombocytopenia comprehensive screening of patients, regular follow-up, especially with heavy bleeding, anemia performance, accompanied by ESR, C3, C4, a variety of anti-nuclear antibodies, such as ANA, ds-DNA, nRNP / Sm, SSA and other immunological tests Abnormal female patients of childbearing age, timely diagnosis and treatment of SLE can thus play an important significance to improve the prognosis.
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