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Paraquat (paraquat, PQ), also known as sweep away the light of paraquat, a commercially available 20% aqueous solution of the trade name Gramoxone, is one of the most widely used herbicide in the world within, to people, livestock are toxic. Paraquat poisoning (paraquat, poisoning, PQP) the incidence increased year by year, the pathogenesis is not yet completely clear that oxygen free radical damage and systemic inflammatory response mechanisms involved in the pathogenesis of the PQP, patients eventually lead to lung injury based organ dysfunction syndrome. PQP lack of a specific antidote treatment, studies show The PQP the fatality rate can be as high as 25% -76%. Existing conventional treatment measures, including gastric lavage, catharsis, glucocorticoids, immunosuppressants, oxygen free radicals, and its treatment is not satisfactory. As effective measures to clear the body of poisons, blood purification technology has been widely used in the PQP the treatment of. The commonly used methods include blood dialysis (HD) blood perfusate (HP), plasma exchange (PE), continuous renal replacement therapy (CRRT). Each blood purification technology has its own strengths and weaknesses. How, in accordance with the characteristics of the blood purification treatment, the patient's condition, toxicological characteristics to optimize the selection is to determine the clinical efficacy of key. Sequential blood purification treatment PQP efficacy reported in China in less paper collected through retrospective case method, the analysis of the treatment of the PQP the efficacy study sequential blood purification treatment PQP provide a theoretical basis for clinical optimization. Objective: The collected through retrospective case analysis of damage organ function compared with conventional treatment group, hemoperfusion group and sequential blood purification treatment group, the difference in survival time and mortality. Explore sequential blood purification treatment PQP clinical efficacy and impact on prognosis, optimize clinical treatment PQP provide a theoretical basis. Methods: A retrospective analysis from January 2005 to January 2011, the Second Clinical Hospital of Jilin University Emergency Medicine (ICU) and the Jilin City Central Hospital Emergency Medicine (ICU) the PQP patients admitted to 122 cases, according to different treatment methods divided into conventional treatment group (42 cases), blood perfusion group (conventional treatment HP) 47 patients, sequential blood purification treatment group (conventional treatment group HP CRRT) in 33 cases of. In accordance with the PQP the clinical standard 122 cases of the PQP patients divided into mild paraquat poisoning in 9 cases, to - severe paraquat poisoning 98 cases, 15 cases of fulminant paraquat poisoning. Analysis of the degree of organ damage in patients compare different treatment groups, the difference between the survival time and mortality. All the data are used the SPSS17.0 package for statistical analysis. Measurement data are expressed as mean ± standard deviation (x ± s) single-factor analysis of variance was used to compare the differences, the same group of patients before and after using the the mean paired samples t-test; count information group compared with the x2 test groups. Results: 1, the conventional treatment group, hemoperfusion group sequential blood purification group the PQP patients age, sex, gastric lavage of APACHE Ⅱ score difference was not statistically significant (p gt; 0.05) comparability; 2, the sequence intersection blood purification organ damage degree of (partial pressure of oxygen in arterial blood, liver function, renal function, serum creatine kinase) below hemoperfusion group and the conventional treatment group, the difference was significant (p lt; 0.05); Sequence intersection blood purification group extend survival time than hemoperfusion group and the conventional treatment group, the difference was statistically significant (p lt; 0.05); 4,122 cases of patients with acute PQP the overall mortality conventional treatment group, hemoperfusion group sequential blood purification between the groups, the difference was not significant (p gt; 0.05). 5 - severe PQP patients, sequential blood purification group mortality below hemoperfusion group and the conventional treatment group, the difference was significant (p lt; 0.05). Conclusion: Sequential blood purification therapy can improve the function of the PQP patients with organ (liver, kidney, cardiac, lung). 2, sequential blood purification treatment, prolong the survival time of patients with PQP. Sequential blood purification therapy can reduce - severe PQP mortality in patients, but can not improve the prognosis of patients with fulminant PQP. 4, sequential blood purification treatment - severe the PQP the efficacy is superior to conventional drug treatment and HP treatment alone. 5 sequential blood purification therapy is an important means of effective treatment - severe PQP and multiple organ dysfunction syndrome.
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