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Obesity and various diseases caused serious harm to human health, weight loss drugs, chemical drugs often cause some side effects so it is difficult to accept, looking for drugs of plant origin and development of safe and efficient, green health weight loss drugs is particularly important. Efficacy trials on this topic in the nutrition obesity model to study a aromatic plants recipe slimming effect of the water extract, a preliminary analysis of its mechanism of action; total flavonoid content of the extracts was determined by spectrophotometry, using UPLC-MS analysis the chemical composition of the extract. An extract of anti-obesity experimental method: Preparation of a the recipe water extract and nutritional obese rat model, extract continuous ig administered for 5 weeks, measurement of body weight, body fat, calculate body mass index, and Lee's index, ELISA serum leptin (LEP), serum lipids four (TC, TG, HDL, LDL) Paraffin sections adipose tissue morphology was observed, determination of serum superoxide dismutase (SOD), malondialdehyde (MDA), total antioxidant capacity (T-AOC), preliminary analysis of the mechanism of drug action. Results: Compared with the nutrition obesity rat model group, the extract dose group (4000,2000,500 mg ยท kg-1) rat body weight and body fat were significantly reduced, the obesity index and Lee's index lower high dose group obesity index was significantly reduced; extract each dose group were significantly lower level of serum LEP, in a dose-dependent manner; obesity model rats lipid parameters was significantly higher than the control group, the extract for regulating blood lipids in obese rats play certain role; sliced ??observations indicate that the fat cells of the high-dose group was significantly smaller, and a significant increase in the number of cells per unit vision; each dose group were significantly increased serum SOD and T-AOC content and MDA, showing a dose-dependent patience. Conclusion: Recipe extract has significant anti-obesity nutrition obese rats may be the way to achieve lower serum leptin, lower blood lipids, increase fat consumption; recipe extract showed good antioxidant effect, and showing dose in accordance with patience; showing a certain correlation between this anti-oxidation and anti-obesity extracted material good anti-oxidation may play a certain role in promoting anti-obesity. Analysis of the chemical composition of the extracts of the two formulations by spectrophotometry with rutin as standard products total flavonoids extract, measurement results measured at 370nm at 15.13%. UPLC-MS identification of the chemical composition of the formula extracts, the results are as follows: from the chemical composition of the aqueous extract identified: rosmanol (2.95%), rosmarinic acid (1.73%), luteolin -7. - glucuronic acid glycosides (1.25%), carnosol (0.40%); the identified chemical composition from the extract alcohol solution: rosemary acid (2.60%), quercetin (0.69%), coffee acid (0.52%), chlorogenic acid (0.29%). The aromatic plants more concentrated in essential oils, and for research and development of the water extract rarely, forming a serious waste of resources, the subject of major research of a water extract of the aromatic plants formulations. The results show that the extract contains a high content of total flavonoids containing the rosmarinic acid rosmanol luteolin -7 - glucuronic SNMC, carnosol, and quercetin, caffeic acid, green acid and other bioactive substances; extract has significant anti-obesity and anti-oxidation, with a potential value of development and utilization. This topic is the finding and development of safe and efficient, new exploration-based formula extract plant source of green health weight loss drug provides an important theoretical basis for further development and utilization;, it is also the research and development of the aromatic plant water extract resources, provides typical examples and an important basis for the comprehensive development and utilization of the aromatic plant resources.
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