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Clean sand particles are in clinical use for many years experience side by Nansha ginseng , skullcap , ephedra and other Chinese herbal medicines , with Qingfei Yin, moistening the effectiveness of cough , caused by damage to Yin Dryness for Hyperactivity cough the main topic of clean sand granules for technology, quality standards and preliminary stability test conducted pharmaceutical research . According to prescription drugs intended reasonable physical and chemical properties of the process line , using orthogonal test and single factor test each drug extraction, purification, concentration , molding and other processes to filter , and ultimately determine the process route is: Ephedra, Imperatorin plus 6 times the amount of 60% ethanol extracted three times, each time one hour , the combined ethanol extract ; Adenophorae with the rest of the dregs of 6 plus 8 times the amount of flavor combined aqueous extract two times, the first 1.5 hours , the second for 1 hour, combined decoction concentrated to a certain density , add ethanol containing 60% alcohol content , mix and let stand the precipitate to room temperature , filtered impurities , the filtrate was combined with the alcohol extract , ethanol recovery and concentrated under reduced pressure to a thick extract , vacuum drying , crushing, in accordance with the proportion of added microcrystalline cellulose, dextrin, spray evenly into 85% ethanol made from grains , 60 ℃ dry, made 1000g, ie. Quality standards in the study , three batches of test products according to the situation of the finished product traits were specified. Identification of each item of each flavor ingredients were carried out by TLC test , skullcap , ephedra, Peucedanum, loquat , Adenophorae TLC income text the product quality standards . Check the moisture content of the finished items , load difference , particle size , melting and other research . HPLC method for the main active ingredient to determine the content of baicalin , and the determination of a systematic methodological study . Data were analyzed according to several batches formulated baicalin content limits , the tentative baicalin this product shall not be less than 20mg / g. Preliminary stability studies at room temperature using retained samples investigated . Results Three batches character, identification , inspection, determination of which adhere to quality standards. Conclusion: The preparation process is reasonable and practicable ; product quality stable and controllable .
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