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Objective: To observe the different time combination of Amlodipine compound amiloride circadian rhythm of blood pressure, blood pressure, and a protective effect on the heart, kidney target organ. Methods: From March 2008 to June 2009 in our hospital, Qianjiang Central Hospital, Shuangqiao District Hospital basis of hypertension criteria were selected 80 cases of patients with hypertension. Eligible patients were randomly divided into two groups: the morning medication group (n = 40) and bedtime group (n = 40). All patients signed informed consent for the collection of the history and age, height, weight and general disable an impact on blood pressure drugs two weeks drug washout. The cleaning after determination of clinic blood pressure and ambulatory blood pressure, blood glucose, triglycerides, total cholesterol, uric acid, ECG, alpha1-microglobulin, β 2 -microglobulin, urine trace protein, transferrin, ultrasound heart diagram and other related inspection. The two groups of patients taking amlodipine 5 mg and half a slice of compound amiloride at 8:00 and 22:00, respectively, and 12 weeks of continuous medication. Medication during the regular follow-up, office blood pressure was measured, and urge patients to take medication on time, to observe whether serious complications. The 12 weekend again ambulatory blood pressure, electrocardiogram, α1-microglobulin, β 2 -microglobulin, urine trace protein, ferritin, ultrasound echocardiography testing, analysis of different times of administration of the blood pressure, morning peak phenomenon, blood pressure mode, as well as heart, kidney target organ protective effects. Results: 12 weekend morning medication, bedtime two groups of patients with antihypertensive efficiency reached 97.5%. Compared with the medication group in the morning, the morning blood pressure surge phenomenon of bedtime patients significantly alleviate nighttime blood pressure decline rate, systolic blood pressure [medication: (13.2 ± 3.3) compared to (9.9 ± 3.6)%; diastolic blood pressure medication after: (13.9 ± 3.8) (10.5 ± 3.2)%] increased significantly more non-dipper hypertensive patients to return for the dipper hypertensive patients with abnormal circadian blood pressure significantly improve and even return to normal. α1-microglobulin, β 2 -microglobulin, urine microalbumin and transferrin, left ventricular mass, left ventricular mass index, interventricular septum thickness, left ventricular posterior wall thickness, left ventricular diastolic diameter sleep before the medication group patients earlier on reduced medication group, but the difference was not significant. Conclusion: different time taking Amlodipine compound amiloride the hypotensive effect there is a difference, the night taking medication to alleviate morning blood pressure surge phenomenon, improve abnormal circadian blood pressure has an obvious advantage compared with the early morning of heart, kidney and target organs the protective effect is more significant.
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