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Objective: 1. Analysis of the relationship between non-Hodgkin's lymphoma patients with 18F-FDG PET / CT standardized uptake value (SUV) with clinicopathological parameters. 2. Analysis of the relationship between serum lactate dehydrogenase (LDH) and clinicopathological parameters. 3 SUV and LDH in the identification of aggressive lymphoma with indolent lymphoma value. 4 Analysis of the correlation between both SUV and LDH. Analysis of the prognostic value of SUV and LDH. Method: statistical line of 18F-FDG PET / CT examination Affiliated Provincial Hospital of Anhui Medical University, Department of Medical Oncology since 2007.1.1-2010.9.1 during NHL patients with a total of 278 cases in our hospital, complete information, confirmed by pathology , 92 cases of patients with previously untreated NHL pre-treatment line LDH check. Statistics patients SUV, LDH, gender, age, stage, B symptoms, bone marrow infiltration, the degree of malignancy and pathological type, parallel Ki67 detection and follow-up of patients overall survival time (OS). SPSS 17.0 software for statistical analysis of the SUV with gender, age, stage, B symptoms, bone marrow involvement, extranodal involvement, Ki67 expression and malignant degree Wilcoxon test to analyze the relationship between the SUV and the clinicopathological parameters ; LDH gender, age, stage, B symptoms, bone marrow infiltration of Ki67 expression, the degree of malignancy Wilcoxon test to analyze the relationship between the LDH and clinicopathological parameters; receiver operating curve (receiver operating characteristic, ROC) Analysis SUV, LDH and the value judgment NHL vicious; correlation using the Spearman rank correlation analysis SUV and LDH; follow-up of patients with NHL OS, and Kaplan-Meier method survival function to describe the survival curves, Log Rank test comparing survival distribution curve Let P lt; 0.05 when the difference was statistically significant. Results: The the SUV and Ki67 positive rate (P = 0.010), gender, age, B symptoms, stage, bone marrow infiltration, the the extranodal difference between statistical significance (P gt; 0.05). LDH and Ki67 (P = 0.010), B symptoms (P = 0.002), bone marrow infiltration (P = 0.015), related to gender, age, stage, no statistically significant difference between the number of extranodal lesions (P gt; 0.05). After the degree of malignancy of the Wilcoxon test, SUV and lymphoma (P = 0.001). Study by the ROC curve, derived SUV aggressive lymphoma diagnosis performance area under the ROC curve = 0.738, standard error of 0.053, P = 0.000, 95% confidence interval (0.635,0.842), does not contain the 0.5. Curve based on test work to find the best threshold SUV = 9.0 (sensitivity 73.0%, specificity 58.6%). After the Wilcoxon test, LDH and lymphoma of the degree of malignancy (P = 0.035). LDH aggressive lymphoma diagnosis performance area under the ROC curve = 0.705, standard error of 0.060, P = 0.002,95% confidence interval (0.588,0.823), does not contain the 0.5. According to the working curve of subjects we find the optimal threshold LDH = 195 (sensitivity 79.4%, specificity 62.1%). SUV and LDH using the Spearman rank correlation analysis to obtain results both positively correlated, the correlation coefficient r = 0.400, P lt; 0.05 SUV gt; 9 median survival of 23 months, SUV ≤ 9 The median survival time of 28 months. Application Kaplan-Meier method of survival function to describe the survival curves of the two groups. The two sets of curves application on Log Rank test p = 0.243, the distribution of the survival of the two groups was not statistically different. Of LDH gt; 195 group had a median survival of 26 months, 195, of LDH ≤ median survival of 28 months. Application Kaplan-Meier method of survival function to describe the survival curves of the two groups. The two sets of curves application on Log Rank test p = 0.039, two groups there are significant difference in survival distributions. Conclusion: SUV and Ki67 expression lymphoma related to the degree of malignancy. 2. LDH and B symptoms, bone marrow infiltration, Ki67-positive rate of lymphoma is closely related to the degree of malignancy. 3. SUV and LDH judgment lymphoma can be used as an indicator of the degree of malignancy. 4. SUV, LDH positive correlation. The 5. SUV and LDH of great value in the judgment prognosis.
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