Dissertation > Excellent graduate degree dissertation topics show

The Comparison of Acyclovir Efficacy between Supported Cerebral MRI and Unsupported to Herpes Simplex Virus Encephalitis

Author: LiMiaoDuan
Tutor: WangNing
School: Fujian Medical
Course: Neurology
Keywords: Herpes simplex virus encephalitis cerebral MRI Acyclovir Glasgow Outcome Scale
CLC: R512.3
Type: Master's thesis
Year: 2011
Downloads: 23
Quote: 0
Read: Download Dissertation

Abstract


Objective The mortality and disability rate of Herpes simplex virus encephalitis (HSVE) significantly reduce with the use of acyclovir .But the therapeutic effect is different in patients. There are several cases suspected to HSVE with clinical symptom. Some in line with HSVE in cerebral MRI,but others do not ,even having normal manifestation . We would like to observe the different effect of acyclovir between supported MRI with those unsupported to HSVE. The relationship between cerebral MRI with therapeutic effect of acyclovir in HSVE has less mentioned by far. Investigate the value of MRI as a marker to predict the prognosis of viral encephalitis.Method We have a retrospective investigation in virus encephalitis which have clinical evidence for HSVE from January 2005 to November 2010 at the neurology department of the First Affiliated Hospital of Fujian medical University. There are fifty-two patients (mean age36.52±16.20 years, male /female 24/28). All patients have cerebral MRI. According to MRI, we divide those patients into two groups. One has supported MRI for HSVE (group supported), the other not (group unsupported). There are without differences between two group in level of concisions and the time of initiating of Acyclovir, follow-up time (P>0.05). All patients have standard treatment of Acyclovir .We study the difference between two groups for these clinical data and effects of acyclovir with GOS score (Glasgow Outcome Scale) in short-term and long-term studies. We analysis the measurement data with normal test and t test and count data withχ2 test by SSPS soft ware .It signs difference if P<0.05.Results There are twenty-seven patients (mean age 38.64±13.96years, male/female 12/15) in nonsupport group, including three patients loss. And, twenty-five patients (mean age 27.30±16.98years,male/female 12/13) in group supported including three patients died in acute stage. Most patients in group unsupported have normal MRI and abnormal behavior. Compared to group unsupported, the supported group have lower GOS score in short and long-term study (Ps=0.005, Pl=0.03), and higher mortality(0%vs12%,0%vs9%) which may be lower than those reported before. The disability rate is without difference between two group in short-term study (P>0.05), The GOS score is improved in two group after discharge (P supported=0.005, P unsupported=0.015).Conclusion HSVE with normal MRI may have good reaction to acyclovir. Compared to group unsupported , Group supported had poor prognosis, higher disability rate and higher mortality rate, which; However had lower disability rate and mortality rate compared to previous literature. GOS increased in long term followed up of both two groups. As for the group unsupported, more clinical symptoms was mental anomaly, and cerebral MRI was always normal.

Related Dissertations

  1. Acyclovir - hydrotalcite intercalation complex preparation process,TQ463
  2. The different honey concentration mesh safety ointment treatment of herpes simplex virus keratitis experimental research,R285.5
  3. The Value of Susceptibility Weighted Imaging in Traumatic Axonal Injury,R445.2
  4. Enzymatic Synthesis of Acyclovir-Saccharide Derivatives and Evaluation of Their Properties,TQ463.5
  5. Rover ethanol extract Lasianthus experimental study of duck hepatitis B treatment,R285.5
  6. The Dynamic Changes of Immunological and Correlative Biochemical Markers in Traumatic Brain Injury and Intervention Effect of Urinary Trypsin Inhibitor in Clinical Control Research,R651.15
  7. Preparation and Characterization of Gelatin Magnetic Targted Drugs,TQ460.1
  8. Study on the Glycosyl Galactose Acyclovir Triparted Pre-drug Nanoparticle Delivery System,R943
  9. Prespective Study of MRI and Cognitive Impairment for Patients with Suspected Herpes Simplex Encephalitis,R512.3
  10. Interactions among Chitosan, Hemoglobin and Drug (Acyclovir and Fuchsin),R96
  11. Study on Drug Prophylaxis Effects on Cytomegalovirus Infection after Liver Transplantation,R512.99
  12. Studies and Applications of Charge Transfer Spectrophotometry in Pharmaceutical Analysis,R917
  13. Asialoglycoprotein receptor-mediated hepatic targeting Acyclovir Preparation and preliminary study,R965
  14. Study on the Synthesis of Intermediate of 9-(2-hydroxyethoxymethl) Guanine,O629
  15. Antimicrobial Susceptibilities of HSV Clinical Isolates to Aciclovir and Valaciclovir and Aciclovir-resistant HSV Strains Isolated by Plaque Purification,R752.1
  16. Study on Pharmacokinetics of Drugs by High Performance Liquid Chromatographic Technique,R96
  17. Study on the Acyclovir Palmitate-Loaded Submicron Emulsion,R94
  18. Studies on the Acyclovir Submicroemulsion for Injection Administration,R94
  19. Preparation of Ultrafine Particles of Drug Using Supercritical Fluid Technology,TQ460.6
  20. Study on Inhibition of Herpes Simplex Virus Type 1 Replication in Vitro and in Vivo and Brain Protection against Infection in Mice by New Antibiotics S632A3,R965

CLC: > Medicine, health > Internal Medicine > Infectious disease > Viral infections > Encephalitis and cerebrospinal meningitis
© 2012 www.DissertationTopic.Net  Mobile