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After the birth of the the development of of the early nervous system of the body is is not yet mature, the any harm to the of the this period sexual stimulation are that may affect the the the the development of of the brain structure, thus changing the the function of activities of the brain. The the stress of the early life is the to caused by the the of important risk factors of the many nerve diseases of the the spirit of sexual, can be induced by the the children with attention deficit disorder, schizophrenia, and autism and other neurological diseases of the the spirit of sexual. After the birth of with the contact the living body is most closely related is the the brain of the mother, mother-child relationship in the the body to was born early development plays a the an important role in. Previous studies have found When the Infants separated from the with the mother a few weeks or more a long time, adult may occur after the different forms of the behavior of abnormalities. Although the the the incidence of mechanism is is currently is not clear, but the study found, such a brain of patients with are there is the the abnormal of forward to monoamine neurotransmitters in. Animal experiments show that female rats is not only is the need to survive by the, Aberdeen, rat, but also a a key factor in of the in young rats nervous system development. Therefore, this study that the in order to, Aberdeen,-mouse early separated into the of experimental factors, the establishment of the animal models. To observe the, Aberdeen, rat early after the separation of on the the the the the impact of and its mechanism of of the rat the wilderness, in the land of great behavior, to explore the with the the the relationship between of the-related brain developmental disorders sexual nerve diseases of the the spirit of sexual. Objective: To observe, Aberdeen, rat early after the separation of on the the the the the impact of and its mechanism of of the rat the wilderness, in the land of great behavior, to explore the with the the the relationship between of the-related brain developmental disorders sexual disease. Method: will 7d in the after birth, Tsai rats were randomly assigned is divided into normal control group, the maternal deprivation group and the the the mother-to-, Aberdeen, separation group. 49d underwent open-field experiment, To observe the the the change the of the rats behaviors in open field, and to display cerebral regions related to dopamine (DA) and 5 hydroxyl color amine (5-HT) the expression of change in order to on the method where you the immune Organization chemical. Results: the 1 open-field of experiments: the the maternal deprivation group and mother-to-, Aberdeen, separation group rats-the vertical movement of score was significantly higher than that normal control group, grooming incubation period noticeably shorter than normal control group (P lt; 0.01). A 2 of immune organization chemical: 1) TH The results of immunohistochemistry: through the optical density analysis found that, rats by the maternal deprivation group tyrosine hydroxylase (TH) in the the in substantia nigra and the the optical density of of the caudate putamen value obvious higher than the normal control group, in the the the substantia nigra, caudate-putamen nuclear dorsal medial area, the the District, of ventral tegmental and the caudate-putamen nuclear intra-abdominal District,, respectively, increased 19%, 11% (P lt; 0.05), 42 between% and and 19% (P lt; 0.01 ). The mother-to-, Aberdeen, separation group than in the is measured at the aggregate of the control group of rats normal, in the the the substantia nigra and caudoputamen dorsal medial area, the ventral tegmental area and caudoputamen intra-abdominal District, was, respectively, higher 21%, 2% (P lt; 0.05), 49% and 8% by (the P-LT; 0.01). 2) the chemical of the DAT immune Organization: optical density analysis found that, the the dopamine transporter of of the maternal deprivation group rats body (DAT) in the substantia nigra, the ventral tegmental area and the the the optical density of value of of the caudate putamen was significantly higher than that normal control group, in the black qualitative, the the ventral tegmental District, and the the caudate-putamen in the ventral medial part of the Do not increased by 23%, 21% and 19% (P lt; 0.01); in the increased the the dorsal medial of the Ministry of of the caudate-putamen nuclear 11% (P lt; 0.05). Than the normal control group rats in connection with the Page 5 5 the DAT rats by the mother-to-, Aberdeen, separation group in the the substantia nigra, ventral tegmental area, caudate-putamen nuclear intra-abdominal Area and the back medial area of, respectively, increased 22%, 15%, 8% (P lt; 0.01) and 8% (P lt; 0.05). 3) The results of TPH immune group oriented: the motherly love deprivation group and the the mother-to-, Aberdeen, separation group rats TPH in the the the dorsal raphe nucleus the the optical density of value of of the at the than the normal control group, respectively an increase of 46% and 42% (P lt; 0.01). In the raphe the dorsal motor nucleus of the ventrolateral region of motherly love deprivation group rats than in the increased the rats of normal control group 47% (P lt; 0.01). 4) 5-HT immune group The results of: the maternal deprivation of rats 5-HT (group and the mother-to-, Aberdeen, separation group) in the the the dorsal raphe nucleus the the optical density of value of of the at the respectively, compared with the normal control group an increase of 54% and 26% (P lt; 0.05 ). In the raphe the dorsal motor nucleus of the ventrolateral region of with the maternal deprivation group and the the the mother-to-, Aberdeen, separation group respectively, compared with increased the rats of normal control group 46% and 28% (P lt; 0.01). Which 5) SERT immunohistochemistry Results: the maternal deprivation group, the SERT between the the mother-to-Aberdeen separation group and the normal control group of rats in the raphe the dorsal motor nucleus of at the there is no significant difference. The the the optical density of value of of the in the raphe rats by the the dorsal motor nucleus of the ventrolateral region of than the normal control group SERT increased 45% (P lt; 0.01). Conclusion: Early Aberdeen mother separation to change the rats of the behaviors in open field; to increase the the substantia nigra, the of TH of the caudate putamen and DAT, as well as the dorsal raphe nucleus of the TPH ,5-HT and SERT the expression of. Implied that the, Aberdeen, Rat the early separation of is very may be related to the the spirit of certain nerve sexual disease, such as the the attention defects disorder, anxiety, autism as well as schizophrenia, and so on the incidence of there is a a certain relationship.
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