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Background: Angiotensin II type 1 receptor is closely related to hypertension, and new evidence has suggested that the autoantibodies to AT1R are present in hypertensive people.Objective: To investigate the relationship of angio- tensin II type 1 receptor （AT1R）, antibodies against angiotensin II Type 1 receptor （AT1R-AA） and blood pressure.Methods: One hundred and thirty-eight subjects were enrolled and separated into three groups according to the Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure （JNC 7）: normotensive （≤120/80 mm Hg, n=31）, pre- hypertensive （120—139/80—89 mm Hg, n=39） and hypertensive （≥140/90 mm Hg, n=68） groups. Plasma AT1R and AT1R-AA were detected by Enzyme-linked immunosorbent assay （ELISA）, tumor necrosis factor-α（TNF-α）, endothelin-1 （ET-1） and angiotensin II （Ang II） by radioimmunity. Results: 1) Plasma levels of AT1R/ AT1- AA, TNF-α, ET-1 and Ang II are increased with blood pressure levels. 2) Plasma AT1R/AT1R-AA are positively correlated with systolic blood pressure,diastolic blood pressure, mean arterial pressure, TNF-α, ET-1 and Ang II, Ang II are also positively correlated with systolic blood pressure,diastolic blood pressure, mean arterial pressure and ET-1. 3) Multipule linear regression analysis showed that AT1R, AT1R-AA and Ang II are independent predictors for systolic blood pressure, mean arterial pressure, AT1R, AT1R-AA are independent predictors for diastolic blood pressure.Conclusion: The expression levels of plasma AT1R/AT1R-AA may reflect the levels of blood pressure. And AT1R-AA is closely related with inflammatory factors, which may also play an important role in the progress of hypertension.
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