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Huanglianjiedu soup of atherosclerosis in a mouse model of intervention

Author: JinHaiQin
Tutor: ZhangJianPing；MaYaZuo
School: Beijing University of Traditional Chinese Medicine
Course: Chinese and Western medicine combined with the basis
Keywords: Hyperlipidemia / atherosclerosis Monocytes Huanglianjiedu soup
CLC: R285.5
Type: Master's thesis
Year: 2011
Downloads: 116
Quote: 0
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Abstract


Research Objective: This study of apolipoprotein E ( Apolipoprotein E ApoE) gene knockout ( ApoE- deficient ApoE -/ - ) mice high-fat diet copy hyperlipidemia / atherosclerosis model by testing mice changes in peripheral blood mononuclear cells immune characteristics research the TCM classic recipe Huanglianjiedu soup and herbs Coptis main component of berberine anti- atherosclerotic mechanisms . Methods: 45 high-fat diet ApOE - / - mice were randomly divided into three groups : the model group , the Huanglianjiedu soup group , berberine group (n = 15); 30 C57BL / 6 mice were randomly divided into The two groups, the control group , high-fat diet control group ( n = 15 ) . Huanglianjiedu soup (5g/kg), berberine (200mg/kg) orally medication once daily , continuous 4w . 4w for each group and , after the detection of immunological characteristics of monocytes and histological staining . Results : mice indicators detect , draw the following results : 1) the model control group mice plasma total cholesterol (TC) levels significantly increased , Huanglianjiedu soup berberine four weeks after the intervention TC levels did not change significantly ; 2 ) model mice increased the proportion of peripheral blood mononuclear cells , monocyte surface receptor CD36 expression increased the the HJD, berberine intervention four weeks after the proportion of monocytes significantly decreased , significant decrease of CD36 expression ; 3) the Huanglianjiedu soup group berberine group monocyte surface receptor of CD80 and CD86 expression was no significant change in the control group compared with the model ; 4) . the soup group of the Huanglianjiedu , the berberine group monocyte subsets proportion with model control group compared with no significant changes. 5 ) berberine group monocyte cell surface receptor TLR - 4 expression compared with the model control group increased significantly . Conclusions: compared with the wild-type mice ordinary diet , ApoE -/ - mice high-fat diet copy hyperlipidemia / atherosclerosis model mice monocytes proportion of its surface receptor CD36 expression increased significantly the intervention four weeks Huanglianjiedu soup can correct this immune disorders and Huanglian immunomodulatory effects independent of their lipid-lowering effects ; Huanglianjiedu soup main ingredient berberine also has immunomodulatory effects , but it mechanism with Huanglianjiedu of soup are not identical.

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