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The Association Between a Single Nucleotide Polymorphism rs11966200 in MHC Region and Clinical Features of Generalized Vitiligo in Chinese Han Population

Author: TangJin
Tutor: YangSen；ZhangXueJun
School: Anhui Medical University,
Course: Dermatology and Venereology
Keywords: Vitiligo Han MHC Single nucleotide polymorphisms Correlation
CLC: R758.41
Type: Master's thesis
Year: 2011
Downloads: 13
Quote: 0
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Abstract


Background Vitiligo Vitiligo is a common depigmentation of the skin and mucous membrane disease . The exact pathogenesis is not yet clear, now widely recognized that vitiligo is a polygenic diseases caused by genetic factors and environmental factors . Our group vitiligo genome-wide association analysis (Genome-wide association study, GWAS) study found that the major histocompatibility complex (Major histocompatibility complex, MHC) region single nucleotide polymorphisms (Single nucleotide polymorphism, SNP) point rs11966200 significantly related to vitiligo vulgaris in Chinese Han population . MHC region SNP rs11966200 in Chinese Han people , the purpose of vitiligo vulgaris age of onset , analysis of the correlation between the extent of the disease , the incidence of type , family history , and associated with autoimmune disease history and other clinical features , which can further understand the MHC region in vitiligo the role played in the pathogenesis . Methods This study cases - cases ( such as age of onset less than or equal to 20 years of age and the age of onset more than 20 -year-old patients ) and case - control (such as the age of onset is less than or equal to 20 years old and the age of onset is greater than 20 -year-old patients with normal control . ) analysis of the MHC region SNP rs11966200 allele differences in order to determine the clinical features associated with this locus . 6366 cases of vitiligo cases and 6,582 cases of the control genotyping ( AA , AG , GG ) information vitiligo genome-wide association analysis of genotyping data from our group . Data after appropriate transformation , social science statistical package SPSS11.0 analysis , P lt ; 0.05 was considered statistically significant . Results age of onset less than or equal to 20-year-old and 20 -year-old patients with vitiligo ( OR = 1.54 , P = 2.01E - 13 ) ; patients with moderate to severe ( skin lesions involving the body surface area ≥ 5 % ) in patients with mild ( skin lesions involving the body surface area lt ; 5 % ) ( OR = 1.17 , P = 0.025 ) MHC region SNP rs11966200 allele difference was statistically significant . 2 alleles between the case and control groups was statistically significant. Conclusion MHC region rs11966200 single nucleotide polymorphisms not only associated with the Chinese Han population vitiligo vulgaris susceptibility , but also may be related to the age of onset and the extent of the disease and vitiligo vulgaris .

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CLC: > Medicine, health > Dermatology and Venereology > Dermatology > Metabolic disorders of the skin > Vitiligo ( vitiligo )
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