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A Study on the Relationship Between the ERCC1 Expression and the Effect of Nedaplatin Treating Advanced Esophageal Cancer

Author: LiXiaoQiu
Tutor: HuBing
School: Anhui Medical University,
Course: Oncology
Keywords: ERCC1 Nedaplatin Immunohistochemistry Advanced esophageal cancer
CLC: R735.1
Type: Master's thesis
Year: 2011
Downloads: 40
Quote: 0
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Abstract


[Objective] Research indicates that nucleotide excision repair cross complementing gene 1 (excision repair cross-complementation group 1, ERCC1) in some common solid tumors (such as gastric cancer, non-small cell lung cancer) in the expression of its platinum-based chemotherapy efficacy related, ERCC1 expression might be predicted platinum-based chemotherapy efficacy indicators. Currently cisplatin fluorouracil advanced esophageal cancer one of the most commonly used chemotherapy regimens, but the second-generation platinum drugs nedaplatin renal toxicity due to their smaller and gastrointestinal reactions, are now widely used in esophageal cancer chemotherapy. In this study, patients with advanced esophageal cancer by detecting pathological tissue expression of ERCC1 levels and in combination with other clinical and pathological features of chemotherapy with nedaplatin disease control rate, progression-free survival time relationship between the study of patients with advanced esophageal tissue resection repair cross complementing gene 1 (ERCC1)-containing combination chemotherapy nedaplatin relationship for selected patients with advanced esophageal cancer chemotherapy drugs to provide a basis. [Methods] A retrospective collection of Anhui Provincial Hospital in December 2009 - December 2010 admitted Ⅳ stage were 102 cases of esophageal cancer patients enrolled, be nedaplatin combined with fluorouracil chemotherapy, disease control rate and simultaneous progression-free survival efficacy evaluation period. Ultimately required 84 patients completed the study and data analysis. All data using SPSS 17.0 software package for statistical analysis, P lt; 0.05 as statistically significant difference. The disease control rate univariate analysis using chi-square test, multivariate analysis using logistics regression model; progression-free survival time on univariate analysis using the Kaplan-meier curve, application Log-rank test and multivariate analysis using Cox proportional hazards survival rate model. [Results] 84 patients have enrolled 84 patients, ERCC1 expression was 88.1% (74/84), the overall disease control rate was 36.9% (31/84), in which expression is lt; 4 persons ( -) in 10 cases, 4 ~ 5 (), 49 cases, 6 to 7 persons () 22 cases, gt; 8 persons () 3 cases; men and 74 cases (88.1%) and 10 females (11.9%), age ≥ 60 years 47 cases (56.0%), lt; 60 years 37 cases (44.0%). All patients with a clear pathological diagnosis, histological type was squamous cell carcinoma of the total, of which 19 cases of well-differentiated (22.4%), 65 cases of poorly differentiated (77.6%); KPS performance status score of 90 points 57 cases (67.9 %), 80 of 22 cases (26.1%), 70 points 5 cases (6.0%). In univariate analysis, disease control rate and ERCC1 expression intensity and related to the degree of tumor cell differentiation, progression-free survival time and ERCC1 expression and tumor cell differentiation degree. In multivariate analysis, the response rate and the recent progression-free survival were similar with ERCC1 expression and tumor cell differentiation degree. [Conclusion] 84 cases of advanced esophageal cancer in the application nedaplatin based combination chemotherapy, ERCC1 expression was negative (lt; 4) and weakly positive patients (4 to 5) relative to the strong positive patients (≥ 5) disease control rate higher and longer progression-free survival, and therefore more suitable for such patients Nedaplatin medication; patients with well-differentiated tumor cells, disease control rate and progression-free survival was significantly better in patients with poorly differentiated, relatively good prognosis of these patients.

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CLC: > Medicine, health > Oncology > Gastrointestinal Cancer > Esophageal tumors
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