Dissertation > Excellent graduate degree dissertation topics show

The Expression of HIF-1Α、ET-1 and VEGF in Colorectal Cancer and Their Clinical Significance

Author: LinChuanBin
Tutor: ZhangCaiQuan
School: Chongqing Medical University
Course: Surgery
Keywords: HIF-1α Et-1 colorectalcancer Immunohistochemistr VEGF
CLC: R735.34
Type: Master's thesis
Year: 2011
Downloads: 43
Quote: 0
Read: Download Dissertation

Abstract


Objective :To explore the expression of HIF-1α, VEGF and Et-1 in colorectal cancer and their Clinical significance.Methods : Immunohistochemistry SABC was used to detect the expression of HIF-1α,VEGF and Et-1 in 60 cases of colorectal carcinomas and 10 cases of cancer adjacent normal tissue,and the relationship between protein expression and clinical pathological features was analyzed . Results:The expression rate of HIF-1α、Et-1 and VEGF protein in cancer tissue were 48.3%(29/60),68.3%(41/60) and 73.3% (44/60) ,While both had no expression in norma1 tissue. The HIF-1αexpression was correlated with depth of infiltration , TNM stage and lymph node metastasis (P<0.05).There was correlation between the Et-1 expression and differentiation degree, depth of infiltration ,TNM stage and lymph node metastasis (P<0 . 05) , The expression of Et-1 increased with HIF-1α(p<0.05). The VEGF expression was correlate with TNM stage and lymph node metastasis P<0.05.Conclusion : HIF-1α, VEGF and Et-1 protein are useful markers for predicting the metastatic potential of colorectal cancer. The expression of HIF-1αwas correlated to that of Et-1, VEGF.Expression of the three proteins suggests a more possibilities of tumor metastasis,and combined analyses of the three markers may be useful in the choice of treatment modalities.

Related Dissertations

  1. Genetic Characterization and Differentiation of Natural Populations of Wild Soybean from Middle and Lower Valleys of Huanghe and Changjiang as Well as Their Genetic Relationship with the Cultivated Soybean,S565.1
  2. Characterization of Population Structure and Linkage Disequilibrium of Chinese Wild Soybean Population and QTL Association Analysis of Traits Related to Breeding for Soybeans,S565.1
  3. Studies on Agrobacterium-midiated Genetic Transformation in Brassica Campestris Subsp. Chinensis Var. Parachinensis,S634.5
  4. Studies on Fingerprint Analysis and Total Flavone Extracts of Saussurea Involucrata ( Kar. Et Kir.) Sch.-Bip.,R284.1
  5. The Analysis of Methods and Clinical Outcome on Short-term Fertilization in In-vitro Fertilization Cycle in Human,R714.8
  6. Effects of Angiopoietin-1 on Vascular Angiogenesis Regulator Factor in Human Umbilical Vein Endothelial Cells Cultured with High Glucose,R587.2
  7. Expression and Significance of HIF-1α on the Insulin Resistance during the Injury of Reperfusion of Ischemic Myocardium in Dog Undergoing Cardiopulmonary Bypass,R654.1
  8. Effects of the Applied External Weak Steady Direct Current Electrical Fields on Diastolic Function after Balloon Injury in the Rabbit Abdominal Aorta,R541.4
  9. The Affection and Correlation of VEGF、 SDF-1 to the Homing of Bone Marrow Hemopoietic Stem Cells in Myocardial Infraction Area,R542.22
  10. Clinical Study on the Expression of VEGF in Liver Metastases of Colorectal Cancer and Its Effect on Prognosis,R735.3
  11. MMP-2, VEGF, CD105, Ki67 in small cell lung carcinoma and prognosis of,R734.2
  12. Experimental Studies on Therapy of Lung Cancer by VEGF-C siRNA Mediated by Liposomes,R734.2
  13. The Role and Mechanism of SDF-1/CXCR4 Axis in Small Cell Lung Cancer Invasion and Metastasis,R734.2
  14. Effect of Thalidomide on Cellular Growth and Angiogenesis of Human Pancreatic Carcinoma Cell Line SW1990,R735.9
  15. Low-dose X-irradiation Promotes Callus Mineralization by Stimulation of Angiogenesis Through VEGF Up-regulation,R687.3
  16. Expression of Fas, NF- κB and VEGF-C in Invasive Ductal Carcinoma of Breast and the Correlation Analysis,R737.9
  17. Effects of Suifotanshinone Sodium on the Growth of SMMC-7721 Hepatoma Cells,R735.7
  18. Expression and significance of TWIST and HIF-1α in cervical cancer,R737.33
  19. Hypoxia Induced Pemetrexed Resistance in Human Non-small Cell Lung Cancer Via Hypoxia-inducible Factor 1α,R734.2
  20. Effect of Rosuvastatin on Plasma Inflammation Factors Levels and Insulin Resistance in Patients with Metabolic Syndrome,R589
  21. Hypoxia Inducible Factor-1 α and DDAH1 Regulation,R363

CLC: > Medicine, health > Oncology > Gastrointestinal Cancer > Intestinal neoplasms > Colorectal tumors
© 2012 www.DissertationTopic.Net  Mobile