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Objective: To investigate the cause of myoclonic epilepsy (myoclonic epilepsy, ME), clinical features, treatment and prognosis for clinical diagnosis, treatment and prognosis provide a theoretical basis. Methods: November 1995 to March 2010 the Children's Hospital of Chongqing Medical University hospital 20 patients with myoclonic epilepsy in children with clinical data, clinical data, including gender, age of first onset, disease duration, clinical manifestations, caused by disease factors, EEG and imaging studies, treatment outcomes were retrospectively analyzed. Results: The group of 20 patients, male: female = 1:1, the average age of onset (3.03 ± 3.55) years, 80.0% less than 8 years old. Possible pathogenic factors accounted for 40.0%, perinatal brain injury, cerebral dysplasia more common pathogenic factors. In the form of clinical seizures, myoclonus is the only form of attack in 10 cases, 10 cases of myoclonus associated with other forms of attack. Diagnosed with juvenile myoclonic epilepsy four cases, five cases of benign infantile myoclonic epilepsy, myoclonic absence epilepsy, myoclonic atonic seizures epilepsy and Lennox-Gastaut syndrome in 3 cases, infantile spasms cases, with broken red fibers myoclonic epilepsy cases not explicitly classified in 2 cases. Interictal EEG is normal in 4 cases, 16 patients with abnormal EEG abnormalities include: mainly spine - slow or spike - slow wave in 9 cases, sharp spines or sharp waves - slow wave in 6 patients, peak imperfectly. Head CT / MRI abnormalities in 6 cases. Commonly used drugs in our hospital during treatment with sodium valproate, clonazepam. 20 patients, 15 cases of seizures in full control of the other five cases of seizures not fully controlled. Valproic acid alone or in combination therapy in 18 cases, complete control rate was 77.8%; possible causative factor group and non-pathogenic factors group were 37.5%, 100.0%; different classification of myoclonus epilepsy efficiency: BIME JME88.9% EMAS100, LGS baby spasms 40, MAE100% with broken red fibers myoclonic epilepsy 0%, 100% of the sub-type is not explicitly. Conclusion: myoclonic epilepsy of complex etiology, clinical myoclonus hair as the main form, prone to misdiagnosis, should raise the attention of the specialist group of the disease and the level of awareness of myoclonic epilepsy. EEG myoclonic epilepsy diagnosis and classification, an important tool for the differential diagnosis. Myoclonic epilepsy prognosis depends first and foremost on parting: BIME, JME prognosis is best, LGS, infantile spasms and poor prognosis, with broken red fibers myoclonic epilepsy worst prognosis MAE most of the prognosis better EMAS is more difficult to judge prognosis. Soon as the diagnosis and classification of myoclonic epilepsy treatment and prognosis is essential. Clear etiology and brain tissue damage also have a greater impact on the prognosis. Strengthen prenatal, perinatal health, prevent and reduce the occurrence of symptomatic myoclonic epilepsy has a very important significance. The treatment should be preferred valproate acid, followed by clonazepam, clonazepam, and lamotrigine triazine; carbamazepine and phenytoin should be avoided so as not to aggravate seizures.
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