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Effect on Neurorehabilitation of HIBD Rats Irradiation with Focused Ultrasound to the Bai Hui Acupoint

Author: LiaoCong
Tutor: ZhouJiangBao
School: Chongqing Medical University
Course: Pediatrics
Keywords: Focused ultrasound hypoxic ischemic brain damage Growth associated protein-43 N-methl-D-aspartate receptors
CLC: R722.12
Type: Master's thesis
Year: 2011
Downloads: 17
Quote: 0
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Abstract


Objective:To expore the effects of focused ultrasound irradiation to the baihui acupoint at neurorehabilitation of hypoxic ischemic brain damaged (HIBD) in neonatal rats.Methods:192 SD rats (7 days old) were randomly divided into sham operation group、model group、acupuncture group and ultrasound group. The HIBD models were induced by using Rice’s, After operation 7 days,14days and 21days the forelimb muscle strength was evaluated by suspension method.The expression of GAP-43 and NMDAR2B in the hippocampal were detected by immunohistochemical and RT-PCR method .Results:1The forelimb muscle strength in ultrasound group were significant improved,as compared model group , and no significant was found between the ultrasound group and the acupuncture group.2The expression of GAP-43 in hippocampus reached the peak at 7 days after hypoxia-ischemia, then decreased gradually at 14 days,but still higer than sham operation group at 21 days. In ultrasound group and acupuncture group, the expression of GAP-43 was much higer than that in HIBD group at three time points.No significant difference was found between the ultrasound group and the acupuncture group.3The expression of NMDAR2B in hippocampus increased and reached the peak at 7 days after hypoxia-ischemia, then decreased gradually and showed an expression similar to sham operation group at 21 days after hypoxia ischemia.In ultrasound group and acupuncture group, the expression of NMDAR-2B was much fewer than that in HIBD group at 7 and 14 days after hypoxia-ischemia ,No significant difference was found between the ultrasound group and the acupuncture group.Conclusion:Focused ultrasound irradiation to the Bai Hui acupoint in HIBD rats can can up-regulate the expression of GAP-43 and reduced the expression of NMDAR-2B,inproved the forelimb muscle strength.

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CLC: > Medicine, health > Pediatrics > Newborns, premature children disease > Neonatal disease > Neonatal asphyxia
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