Dissertation > Excellent graduate degree dissertation topics show

TNF-α and IL-2 Expression in Liver Allograft Rejectoin

Author: FanBin
Tutor: LiDeWei
School: Chongqing Medical University
Course: Surgery
Keywords: Liver transplantation TNF-α IL-2 Rejection
CLC: R657.3
Type: Master's thesis
Year: 2011
Downloads: 11
Quote: 0
Read: Download Dissertation

Abstract


ObjectivesTo investigate the expression of TNF-αand IL-2 in acute rejection response following liver transplantation, and evaluate their roles to be used as markers of acute rejection.MethodsBy establishing orthotopic rat liver transplantation models, Real-time fluorescent quantitative reverse transcriptase polymerase chain reaction (RT-PCR) was used to detect the gene expression of TNF-αand IL-2 in the graft for diagnosis of acute rejection after liver transplantation in rats. The diagnosis of acute rejection was based on histopathology. The relationship between the TNF-α/IL-2 expression and acute rejection was analyzed.ResultsThe mean levels of TNF-αand IL- 2 in liver tissues on days 3、5and 7 were significantly higher in allogene group than those of isogene group.ConclusionsTNF-αand IL-2 expression seemed to be related to the development of acute rejection following liver transplantation,and might be served as sensitive and reliable markers in diagnosing acute rejection in early stage.

Related Dissertations

  1. Attitude Control of a Three-Axis Stabilized Satellite,V448.22
  2. The Research on Paper Currency Classification Method Based on Harr-Like Feature and Minimal Ball Including Samples,TP391.41
  3. Inhibition of RAW264.7 Macrophage Inflammatory Cytokines Release by Guggulsterone,R285
  4. Infectious Bursal Disease Virus Particle Vaccine Research and Its Immune Efficacy Evaluation,S858.31
  5. Roles of MMP-7 and Lysozyme in the Pathogenesis of Ulcerative Colitis Induced by DSS in Balb/c Mice,S858.91
  6. Preparation of Monoclonal Antibody to Porcine TNF-α and Expression of TNF-α in PAM Infected with PRRSV,S858.28
  7. Live alone the study of parasitic soup rabbit lumbar disc herniation model in vivo tumor necrosis factor in rats,R285.5
  8. Cysteamine on T Lymphocyte Proliferation in Post-Operation Goats and Its Mechanism Underlying,S858.27
  9. Cloning, Expression and Bioactivity Analysis of Goat Interleukin-1β and Interleukin-6,S827
  10. Meridians of Asthma Thread Burying Model Rats IL-4 Such Impact Experimental Study,R245
  11. Role of G31P in Smooth Muscle Migration of A7r5 Cells Induced by Interleukin-8,R363
  12. The Expression and Mechanism of NF-κ B and IL-6 after 90% Portal Vein Ligation in Rats,R657.3
  13. The Sequence Analysis of RNA Components from Lactobacillus Metabolites and Parts of the Biological Function,R378
  14. Noble Dendrobium Polysaccharides Attenuate Learning and Memory Deficits Induced by Lipopolysaccharide and Its Mechanisms in Rats,R285.5
  15. Effect of Grape Seed Procyanidins on the Blood Pressure in Renovascular Hypertensive Rats and Its Mechanism,R544.1
  16. Experimental Study on 420nm Intense Pulse Light in Animal Acne Model,R758.733
  17. Biological Effects of Soluble CD40 Ligand on Leukemia HL-60 Cells and Its Mechanism,R733.7
  18. Cloning and Expression Analysis of NCCRP-1 AND IL-10 Genes in Grass Carp (Ctenopharyngodon Idellus),S917.4
  19. Clinical Observation of Ditan Soup in Treating PSD,R277.7
  20. Exploreing the Mechanism of Xieshifeiaifang Ii on Treating Lung Cancer with Pleura Effusion,R734.2
  21. Study on the Correlation Between the Levels of Il-18, IL-33 and Other Inflammatory Factors and Pulmonary Function in Different Stages of Asthma,R562.25

CLC: > Medicine, health > Surgery > Of surgery > Abdominal surgery > Liver and liver tube
© 2012 www.DissertationTopic.Net  Mobile