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Background and purpose of acute pancreatitis, the pancreas to digest the pancreas and surrounding organs to produce digestive enzymes are abnormal activation of inflammatory disease caused, is a common surgical abdomen. Under normal conditions, the pancreas has a series of protection mechanisms to avoid the pancreas itself enzyme damage, the presence of most of the digestive enzymes of the pancreas cells expressed in the unactivated zymogen form, these zymogens present in the acinar cells of the zymogen particles. Trypsinogen slightly alkaline conditions can be automatically activated, while the the zymogen granules PH weakly acidic, trypsinogen stability can be maintained. Maintain zymogen inactivated form of the pancreas to maintain the normal function of the key to the contrary, any causes the zymogen timely activation is causative factors of acute pancreatitis in advance. The clinicopathological often divided into two kinds of mild and severe acute pancreatitis. Severe acute pancreatitis (SAP) is a rapid onset, rapid development, more complications and high mortality of severe acute abdomen. Abrupt onset and rapid development in the SAP the late, more than 80% of the patients died of sepsis and multi-organ failure (MOF). The occurrence of sepsis and MOF pancreas and surrounding tissue necrosis, secondary infection is closely related to the main reason for the SAP late death. Therefore, prevention of the pancreas secondary infection, necrotic pancreatic tissue infections are the main objectives of the SAP treatment. Although a variety of surgical and non-surgical treatment technology to improve the the SAP treatment success rate, but the mortality rate and no significant decline. Therefore, to investigate the incidence of secondary infections in patients with severe acute pancreatitis, predisposing factors, and prognostic factors conducive to improve clinicians' understanding of SAP, SAP's effective prevention, timely diagnosis, early treatment play positive role, in order to avoid or reduce the SAP combined incidence of pancreatic infection, to reduce the mortality and improve the cure rate; reduce medical costs also played an extremely important role. Methods This study retrospectively analyzed the medical records of 102 patients with severe acute pancreatitis patients, emergency surgery from May 2008 to July 2010, admitted to our hospital, 40 patients with secondary infection of the pancreas, non-infected patients 62 cases, and the second generation of the Acute Physiology and Chronic Health Evaluation (APACHE Ⅱ) analyze it; patients with CT findings, causative factors, serum amylase, intestinal function recovery, as well as admission hematocrit blood calcium, blood glucose, serum albumin, hemoglobin concentration, and other related factors were analyzed; SAP patients infected infection group and non-infected group of patients with the clinical data before and after the secondary infection and infection group and non-infected group The parameters of comparison, the data used for univariate homogeneity of variance analysis, measurement data using t test, count data between the two groups using the X2 test multi-factor Logistic regression analysis. All data are used SPSS 13.0 statistical software for analysis. 40 patients with pancreatic secondary infection results in the study of 102 patients with severe acute pancreatitis patients, 39.22% of the total incidence of non-infected 62 patients with severe acute pancreatitis secondary to pancreatic infection, pancreatic infection group non-infected group at the time of admission APACHE II score, serum calcium, intestinal dysfunction ≥ 5 days, hypoxemia, pancreatic necrosis complicated by MODS and pancreatic infection was statistically significant (P lt; 0.05 or P lt; 0.01), while the patients in age, gender, serum amylase, blood glucose, serum albumin, hemoglobin, and pathogenic factors (biliary and non-biliary) no significant difference (P gt; 0.05). Infected group and non-infected group admission comparing the infected group APCHEII rated higher than the non-infected group (P lt; 0.01), the infected group calcium is lower than non-infected group (P lt; 0.01), infection group hypoxemia ( P lt; 0.05) and concurrent MODS (P lt; 0.05) the occurrence of a higher rate of intestinal dysfunction incidence ≥ 5 days was also higher than the non-infected group. The extent and scope of necrosis infection group in CT abdominal CT performance, higher than that of non-infected group (P lt; 0.05), logistic regression analysis showed that patients with severe acute pancreatitis secondary pancreatic infection related factors: blood calcium level , the time intestinal dysfunction, the extent and scope of pancreatic necrosis with MODS factors caused pancreatic infection significantly correlated. Conclusion serum calcium levels were significantly lower intestinal dysfunction ≥ 5d, pancreas obvious necrosis, concurrent MODS is the main predisposing factors for pancreatic infection.
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