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(Iso)thioureas are widely used not only as anti-cancer, anti-tubrculosis, anti-HIV drugs, but also as fungicides, herbicides in the field of medicine and pesticide. Fluorine element was also found to be widely used in medicine and pesticide because of its special nature. At present, the research of fluorinated thioureas in pharmaceutical, chiral catalysis is hot-spot.In this thesis, forty-one fluoride (iso)thioureas compounds and thiazole ketones were synthesized. The structures of synthesized compounds were confirmed by NMR, HR-Mass, IR spectra. The reaction conditions from thiourea to isothiourea including solvents, temperature, catalyst etc. were investigated. The optimization improved the efficiency of the reaction and increased the yield. Their insecticidal, herbicidal, fungicidal activity and the inhibition activity againstβ-N acetyl hexosaminidase, cyclophilin A (CypA), FP-2 enzyme and DHODH were tested. The primary tests showed that no obvious insecticidal, herbicidal and fungicidal activity. However, some compounds showed certain inhibitory activity againstβ-N acetyl hexosaminidase, and the inhibitory activity of B3 and B5 reached to 35% and 36%, respectively. Compounds B1, C1, C2, C4 and C5 showed better inhibition to DHODH. The inhibition is from 53% to 97.7% at the concentration of 10μm. Among them, C2 showed the best activity and its’IC50 value is 0.969μM, which suggested that the further modification could be carried out to find new lead structure with higher activity.
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