Dissertation > Excellent graduate degree dissertation topics show

Clinical Significance of Cytokines Level Changes in Gingival Crevicular Fluid in Patients with Chronic Periodontitis

Author: WangBo
Tutor: GongLin
School: Liaoning Medical
Course: Clinical Stomatology
Keywords: Chronic periodontitis interleukin cytokine IL-1β PGE2 IL-10
CLC: R781.42
Type: Master's thesis
Year: 2011
Downloads: 96
Quote: 0
Read: Download Dissertation

Abstract


ObjectiveThe aim of this study was to examine the effect of phase I periodontal treatment on the levels of interleukin (IL)-1β, PGE2, and IL-10 in gingival crevicular fluid(GCF) in patients with chronic periodontitis.MethodsThe Data were obtained from 50 patients with chronic periodontitis and 30 healthy controls. GCF was collected from at least four pre-selected sites (one shallow, at least two moderate, or at least one deep pockets) in patients with chronic periodontitis. In the healthy group, GCF samples were collected from one site. The cytokine levels were determined by an enzyme-linked immunosorbent assay. Probing depth, clinical attachment level (CAL), gingival and plaque indices, and bleeding on probing were measured. The GCF sampling and clinical measurements were recorded at baseline and 6 weeks later after periodontal treatment. Data were tested statistically by t test.ResultsIL-1βlevels were significantly higher at the moderate and deep pocket sites compared with the shallow sites (P<0.05). After periodontal therapy, IL-1βlevels were significantly reduced in the moderate and deep pocket sites (P<0.05). PGE2 levels at baseline of the moderate and deep pocket sites were significantly lower than the control sites (P<0.05). IL-10 levels were similar in all pockets and did not change after periodontal therapy.ConclusionsThe periodontal treatment improves the clinical parameters in patients with chronic periodontitis, and this improvement is evident in deep pocket sites for pocket depth and CAL values. These results confirm that IL-1βis effective for evaluating the periodontal inflammation and can thus be used as a laboratory tool for assessing the activity of periodontal disease.

Related Dissertations

  1. Inhibition of RAW264.7 Macrophage Inflammatory Cytokines Release by Guggulsterone,R285
  2. The Preliminary Study on Interleukin-10 Transgenic Mice,Q78
  3. Molecular Biological Characteristics of Multiple Porcine Fc Gamma RⅡB Sub-isoforms Generated by Alternative Splicing,S828
  4. Study on the Expression and Bioactivities of Porcine Interleukin-2/6 Fusion Protein in Vivo and in Vitro,S858.28
  5. The Influence in Different Route of Medication with Vitamin A on CD4~+CD25~+ Regulatory T Cell and Cell Factor of IL-4、 IFN-γ in a Rat Persistent Asthma Model,R562.25
  6. Observastion on Histomorphology, Ultrastructure and Expression of TNF-α, IL-1β of Unbalance of Dynamic and Static Forces Cervical Degeneration Disc in Rat Model Abstract,R681.55
  7. Cloning, Expression and Bioactivity Analysis of Goat Interleukin-1β and Interleukin-6,S827
  8. Investigate Patients with Rectal Flurbiprofen on Postoperative Immune Function,R614
  9. Noble Dendrobium Polysaccharides Attenuate Learning and Memory Deficits Induced by Lipopolysaccharide and Its Mechanisms in Rats,R285.5
  10. Effect of Grape Seed Procyanidins on the Blood Pressure in Renovascular Hypertensive Rats and Its Mechanism,R544.1
  11. Cloning and Expression Analysis of NCCRP-1 AND IL-10 Genes in Grass Carp (Ctenopharyngodon Idellus),S917.4
  12. Effects on Recombinant Human Interleukin-10 of IL-2, IFN-γ, GCs, T Cell Apoptosis in Transplantation of the Rabbit Skin,R392
  13. Association of Interleukin-6 Gene Polymorphisms with Susceptibility to Coronary Heart Disease in Asian Populations: a Meta-analysis,R541.4
  14. Study on the Correlation Between the Levels of Il-18, IL-33 and Other Inflammatory Factors and Pulmonary Function in Different Stages of Asthma,R562.25
  15. Effect of Etiasa on the Expression of MMP-2 and TNF-α in Rat Model of Ulcerative Colitis,R574.62
  16. Diagnosis Value of Cytokine Levels and TB-Ab in Serum in Children Tuberculosis and Latent Tuberculosis Infection,R725.1
  17. Bronchial asthma serum interleukin -16 Determination and clinical significance,R725.6
  18. p38MAPK on allergic rhinitis peripheral blood mononuclear cells IL-4, IL-5 effects,R765.21
  19. Effects of Lymphocytes-Derived Catecholamines on the Differentiation of T Helper Cells,R392
  20. Risk Factors of Stroke-associated Infection and Its Correlation with Stress Response and Cell Immunity,R743.3
  21. Study of Dendriti Cell Treatment Combined with Chemotherapy for Late Gastric Cancer,R735.2

CLC: > Medicine, health > Oral Sciences > Oral medicine > Periodontal disease > Periodontitis and weeks meningitis
© 2012 www.DissertationTopic.Net  Mobile