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Background: Vascular complications are the major chronic complications of diabetes, and seriously affect the life expectancy and quality of life of diabetes patients. Endothelial dysfunction (endothelial dysfunction, ED) is a common pathological basis of diabetic vascular disease, diabetic vascular complications originating and contributing factor. Different glucose metabolism in patients with abnormal state presence of endothelial dysfunction, diabetes, high blood sugar caused by oxidative stress plays an important role in the injury of vascular endothelial cells. Therefore, in recent years on vascular endothelial function and oxidative stress in diabetes and its vascular complications mechanism in the development of research has become a hot spot. Objective: To detect the different glucose metabolism in situations of vascular endothelial function and oxidative stress levels, to understand the changes in the glucose load glucose metabolism in situations of vascular endothelial function and oxidative stress levels, and to explore nateglinide in newly diagnosed type 2 diabetes patients with vascular endothelial function and oxidative stress. Methods: Endocrinology, Beijing Hospital, Ministry of Health clinic age 35-65 years of age with suspected diabetes, 109, signed informed consent, underwent oral glucose tolerance test (OGTT), fasting glucose (FPG) and 75g glucose load after two hours high blood glucose (PPG), insulin, C-peptide, glycosylated hemoglobin (HbA1C), glycated serum albumin (GA), lipids, liver and kidney function, blood uric acid; respectively, in fasting and 2 hours after 75g glucose load using resolution ultrasound of the brachial artery flow-mediated endothelium-dependent vasodilation (FMEDD) detection and serum nitric oxide (N0) and endothelin (ET-1) and serum malondialdehyde (MDA), superoxide dismutase (SOD). According to the 1999 WHO diagnostic criteria for diabetes, the subjects were divided into newly diagnosed type 2 diabetes (43), the prediabetes group (33) and normal control group (33). Analysis of differences in three groups of related metabolic markers and vascular endothelial function, oxidative stress indicators, comparing each group after the glucose load above indicators of differences, analysis of the correlation of the vascular endothelial function and oxidative stress indicators and metabolic indicators. Nateglinide (120mg Tid) treatment of newly diagnosed type 2 diabetes patients given four weeks before making the detection and analysis of changes in the metabolic indicators before and after treatment, and vascular endothelial function, oxidative stress indicators. Results: The three groups of normal control group, the group of pre-diabetes, newly diagnosed type 2 diabetes group, FPG, PPG, and their difference (DPG), HbA1C, GA, after 2 hours of fasting and glucose load FMEDD, SOD among the three groups a significant difference (P lt; 0.01). Newly diagnosed type 2 diabetic group and normal control group, fasting and 2 hours after glucose load were significantly different (P lt; 0.05) NO, HDL-C, and HOMA-IRI. Three groups after glucose load than fasting FMEDD NO, SOD were significantly decreased, there is a significant difference (P lt; 0.01); in the normal control group and newly diagnosed type 2 diabetes group, ET-1, MDA were significantly liter high, there is a significant difference (P lt; 0.01). After 2 hours of fasting and glucose load FMEDD with FPG, PBG, HbA1C, GA was negatively correlated (P lt; 0.01), with NO, SOD, HOMA-β was positively correlated (P lt; 0.05). DPG with FPG, PPG, and HbA1C, GA, HOMA-IRI, TG was positively correlated (P lt; 0.01), with fasting and glucose load after 2 hours FMEDD, NO, SOD was negatively correlated (P lt; 0.05). GA with FPG, PPG, HbA1C, DPG was positively correlated (P lt; 0.01), and fasting glucose load the two hours after FMEDD, NO, SOD, HOMA-β was negatively correlated (P lt; 0.01). HbA1C and FPG, PPG, and GA DPG, HOMA-IRI was being related (P lt; 0.01), with fasting and glucose load after 2 hours FMEDD, NO, SOD, of HDL-C, HOMA-β was negative related (P lt; 0.05). Newly diagnosed type 2 diabetes nateglinide before and after treatment, FPG, PPG, DPG, GA, HbA1C, HOMA-IRI have significantly decreased, there is a significant difference (P lt; 0.01); fasting and 2 hours after glucose load FMEDD NO, SOD was significantly higher (P lt; 0.01); ET-1, MDA decreased significantly (P lt; 0.01); LDL-C, ALT, AST decreased significantly, there is a statistically significant difference (P lt; 0.05); TC, TG, CRE downward trend, HDL-C, HOMA-β upward trend, but no statistical difference (P gt; 0.05). Conclusion: 1, pre-diabetes the of those FMEDD and anti-oxidative stress indicators significantly decreased in newly diagnosed patients with type 2 diabetes further significantly reduced. After glucose load the three groups FMEDD and anti-oxidative stress indicators are significantly decreased after the glucose load in newly diagnosed patients with type 2 diabetes significantly increased oxidative stress indicators. 3, blood sugar levels and endothelial dysfunction is associated with the increase in blood glucose levels, increased endothelial dysfunction. After glucose load glucose fluctuations can affect FMEDD, NO, SOD. 4, nateglinide make the newly diagnosed patients with type 2 diabetes lower blood sugar, improve insulin resistance, reduce the oxidative stress status and improve endothelial function.
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