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Objective: the normal ideal blood pressure group and high-normal blood pressure group carotid artery blood flow shear force size measurement and serum monocyte chemoattractant protein -1 (MCP-1) and E- selectin ( E -selectin ) the level of detection , designed to : (1) investigate the changes and clinical significance of high normal blood pressure , carotid blood flow shear stress and endothelial cell function ; ( 2 ) to explore the impact of shear stress on endothelial cell function . Method: screening of 50 normal ideal blood pressure (OBP group ) and 100 cases of high-normal blood pressure the (HNBP group) , high - resolution sonographic instrument were used to measure the two sets of carotid blood flow shear force , and the use of ELISA. serum MCP - 1 and E- selectin concentration, simultaneous detection of body mass index (BMI), fasting blood glucose , total cholesterol, triglycerides , using SPSS13.0 version of statistical software for analysis , the main statistical indicators of normal test The homogeneity of variance test groups were compared using the t-test , correlation analysis using Pearson correlation analysis and linear correlation analysis ; -tailed p lt ; 0.05 difference was statistically significant . Results : ( 1 ) general information , high-normal blood pressure group systolic blood pressure , diastolic blood pressure higher than that of the control group (P lt; 0.01), body mass index ( BMI ) , blood sugar, blood lipids , gender , age , and the control group was not statistically significant ( P lt; 0.05); (2) compared with the normal control group , the high-normal blood pressure group carotid blood flow shear force decreased , the difference was statistically significant ( t = 7.73 , P lt ; 0.01 ) ; ( 3 ) normal compared to the control group , the high-normal blood pressure, serum levels of MCP - 1 and E- selectin water increased by an average , the difference was significant ( t MCP - 1 = 6.38 , P MCP - 1 <0.001; tE- select elements = 15.28 , PE - selectin lt ; 0.01) ; ( 4 ) correlation analysis showed serum MCP-1 and E-selectin was a positive correlation ( r = 0.860 , P lt; 0.001 ) ; (5) Pearson correlation analysis showed that carotid blood flow shear force and serum MCP - 1, E- selectin showed a negative correlation ( rMcp -1 = -0.977 , rE -sel = -0.929 , P lt; 0.001). Conclusions : ( 1 ) high-normal blood pressure who may exist carotid blood flow shear force decreased ; (2) high-normal blood pressure by endothelial dysfunction exists .
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