Dissertation > Excellent graduate degree dissertation topics show

Association of A1166C Polymorphism in AT1R Gene with the Occurrence of AMI and the Extent of Coronary Artery Stenosis in AMI Patients

Author: PengJianYe
Tutor: GuiQingJun
School: Nanhua University
Course: Cardiovascular within science
Keywords: angiotensinⅡtype 1 receptor gene polymorphism acute myocardial infarction coronary artery stenosis
CLC: R542.22
Type: Master's thesis
Year: 2011
Downloads: 18
Quote: 0
Read: Download Dissertation

Abstract


Objective: To study the relationship between A1166C polymorphism in angiotensinⅡtype 1 receptor (AT1R) gene and occurrence of acute myocardial infarction (AMI) and the extent of coronary artery stenosis in AMI patients. According to the results, we may find a new theory to prevent or treat AMI patients on the basis of their medical conditions.Methods: The A1166C polymorphism of 105 primary AMI patients and 111 healthy control subjects was detected by polymerase chain reaction and restriction fragment length polymorphism(PCR-RFLP). All AMI patients underwent coronary angiography and the number of affected coronary vessels (≥50% stenosis) or the Gensini score were determined by the results of coronary angiography. Then some risk factors of coronary artery disease(CAD) were assessed. The relationship between A1166C polymorphism in AT1R gene and occurrence of AMI, the number of affected coronary vessels (≥50% stenosis) and the Gensini score in AMI patients were explored.Results: Neither the genotype frequencies of AA, AC + CC (P>0.05) nor the allele frequencies of A and C (P>0.05) differ significantly between the patients and controls. The genetic and environmental risk factors were studied by Logistic regression analysis. The results showed that hypertension, family history of CAD, high density lipoprotein cholesterol(HDL-C), low density lipoprotein cholesterol(LDL-C) were closely related to AMI(P<0.05). HDL-C was the protective factor (OR<1, 95% CI 0.155~0.931), the remaining three were risk factors (OR>1). Either the number of affected coronary vessels or the Gensini score in AC+CC genotype carriers was significantly higher than that in AA genotype carriers(P<0.05).Conclusions: The A1166C polymorphism in AT1R gene is not associated with the occurrence of AMI but the extent of coronary artery stenosis(number of affected coronary vessels and Gensini score).

Related Dissertations

  1. The Value of the Heart-Type Fatty Acid Binding Protein in Early Diagnosis of Acute Myocardial Infarction,R542.22
  2. CYP2C19 Gene Polymorphism in Patients with Ischemic Cerebrovascular,R743
  3. The Relationship of Polymorphisms of Methionine Synthase Reductase(MTRR) Gene and Plasma Homocysteine Levels with Myocardial Infarction,R542.22
  4. Dual-source CT in the Diagnosis of Coronary Artery Stenosis: a Meta Analysis,R541.4
  5. Association of Interleukin-6 Gene Polymorphisms with Susceptibility to Coronary Heart Disease in Asian Populations: a Meta-analysis,R541.4
  6. Study on Clinical Value of High-sensitivity Cardiac Troponin T Assay in Myocardial Infarction,R542.22
  7. The Influence of Acute Myocardial Infarction(AMI) Area by Transplanting Bone Marrow Stromal Stem Cells(MSCs) with Different Methods,R542.22
  8. Study of the Expression of Toll-like Receptor 2, 4mRNA and Polymorphisms of Patients with Leprosy,R755
  9. MDR1 and CYP3A gene polymorphisms on digoxin plasma concentrations of,R96
  10. On the presence or absence of previous angina pectoris in patients with acute myocardial infarction risk factors and clinical characteristics of,R542.22
  11. Heart rate variability and coronary artery disease and prognosis of acute myocardial infarction,R541.4
  12. Relatinship of the Small, Dense Low-density Lipoprotein with Coronary Heart Disease and the Stenosis of Coronary Arteries,R541.4
  13. The Association of ApoB and ApoAI Gene Polymorphism with Dyslipidemia in Han Chinese of Xinjiang Shihezi,R589.2
  14. The Related Analysis about QT Interval Variability,HRV and the Occurrence of Ventricular Arrhythmias in Acute Myocardial Infarction,R542.22
  15. SLC2A9 gene eighth exon 137A / G polymorphism and diabetic patients with hyperuricemia relationship,R587.1
  16. Relationship between the PAPP-A Gene Polymorphism and Ischemic Cerebrovascular Disease,R743
  17. Relationship between the Gene Polymorphisms of Platelet Glycoprotein Ⅲa PLA and Ⅰ a807C/T with Aspirin Resistance,R541.4
  18. Correlation of Aberrant Methylation of p16, APC Gene to MTHFR, TS Genetic Polymorphisms in Hepatic Carcinoma,R735.7
  19. Associations of BAFF rs 9514828 Polymorphisms with Myasthenia Gravis,R746.1
  20. Impact of CYP3A4*1G Polymorphism on Metabolism of Fentanyl in Chinese Patients Undergoing Lower Abdominal Surgery,R614
  21. The Expression of DNA Adducts dA in Chronic Atrophis Gastritis, Precancerous Lesions and Gastric Cancer and the Relationship with the CYP2E1 Gene Polymorphism,R735.2

CLC: > Medicine, health > Internal Medicine > Heart, blood vessels ( circulatory ) disease > Heart disease > Myocardial diseases > Myocardial infarction
© 2012 www.DissertationTopic.Net  Mobile