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Experimental Research of the Traditional Chinese Medicine DCS Treats the Soft Tissue Injury

Author: ZhangGuiFu
Tutor: WangZhiYi
School: Liaoning Medical
Course: Traditional Chinese Medicine
Keywords: Traditional Chinese medicine Chong scattered down Soft tissue injury Experimental study Prostaglandin E2 Blood rheology
CLC: R285.5
Type: Master's thesis
Year: 2011
Downloads: 71
Quote: 0
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Abstract


The purpose of the pre-clinical observation that traditional Chinese medicine or create casual treatment of soft tissue injury significant clinical effect. Local change of the damaged tissue PGE2 content in this experiment down Chong scattered therapy Chinese medicine, hemorheology changes its treatment of soft tissue injury mechanism. And prove that this mechanism the light microscope rating by HE staining. Healthy adult New Zealand rabbits without injury 52 months of age 6 months, body weight 2.5-3.0kg, male and female. Modeling before New Zealand rabbits adaptive feeding 1 week, 24 hours prior to the experimental rabbit outside of the right thigh hair cut with scissors, then cover with 6% sodium sulfide depilatory hair removal. Modeling method according to Zhou Guolin one animal soft tissue injury in experimental methods (slightly modified). Before modeling randomly divided into control group (group I), model group (group II), Voltaren drug control group (group III - prostaglandin synthesis inhibitor) or invasive the bulk drug group (group IV), each to 13. Modeling 30 minutes after the start of the administration, or create bulk drug group forming of water to down Chong scattered after the injury paste approximately 3x 3c m coated with gauze and taped down to create bulk drugs, drug thickness of 0.5cm per Day deposited; Voltaren drug control group using Voltaren Emulsion treated the affected area and gently rub the product to penetrate the skin, commonly used product is 7% of the dose (refer to human and animal body surface area equivalent dose rate table), 3-4 times a day; model control group and blank control group does not use any drugs. During the five days of treatment, 13 days after each randomly selected six rabbits with 10% chloral hydrate anesthesia with intraperitoneal ear vein of tissue and blood samples (abdominal aortic blood) to be tested, blood for blood Determination of rheological (viscosity of whole blood and plasma viscosity), the organization the PGE2 content determination and HE staining under light microscope to observe the recovery. Result, blood rheology results compare 1 model group and control group, the difference is significant (P lt; 0.01), soft tissue injury when the indicator changed significantly. 2, model group and TCM group was statistically significant (P lt; 0.05), traditional Chinese medicine treatment of soft tissue injury or create scattered significant effect on the index. 3, the Chinese Medicines and Fu Lin whole blood viscosity was no difference (P GT; 0.05), no significant difference in both the treatment of soft tissue damage in the indicators. 4, the Chinese Medicines and Rotary his forest plasma viscosity was statistically significant (P lt; 0.05), significant difference in both the treatment of soft tissue damage in the indicators. PGE2 content was measured results of the comparison model group and blank group differences significant significantly (P lt; 0.01), soft tissue injury when the index occurred significant changes; Chinese medicine group and model group compare differences in sexual significant significantly (P lt; 0.01) medicine or create bulk treatment of soft tissue injury on the index effect is remarkable; Chinese Medicines Voltaren group was not statistically significant (P GT; 0.05), no significant difference in both the treatment of soft tissue damage in the indicators. Three significant light mirror observed score (5,13 days) after the results of comparison of Chinese medicine group and model group compare differences in sexual (P lt; 0.01), traditional Chinese medicine or create scattered treatment effect of soft tissue injury significantly; help his forest group and model group compare differences in sexual significantly significantly (P lt; 0.01) instructions to help his forest treatment of soft tissue damage effect is remarkable; comparison between traditional Chinese medicine group and blank group without statistical significance (P gt; 0.05), description of the modeling of such efforts after traditional Chinese medicine or create scattered 13 days treatment The basic after partial damage to the soft tissue close to normal tissue. The naked eye observation after 13 days of treatment down-invasive the bulk drug group and Fu Lin drug control group rabbit is relatively quiet, the rabbit model group is relatively irritability and escape the phenomenon is still evident. Conclusions medicine or Chong scattered in the treatment of soft tissue injury mechanism may reduce inflammatory mediators PGE2 content of local tissue damage, reduce the damage animal blood viscosity (whole blood viscosity and plasma viscosity), so as to improve hemorheology, accelerate tissue repair, HE Stained recovery also proved its mechanism.

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CLC: > Medicine, health > Chinese Medicine > Of Pharmacy > Pharmacology > Chinese medicine Experimental Pharmacology
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