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Preparation of PAMAM/Bi2S3 Nanoparticles

Author: LiuZuo
Tutor: GaoJianPing
School: Tianjin University
Course: Organic Chemistry
Keywords: PAMAM dendrimer contrast agent nanoparticles
CLC: TB383.1
Type: Master's thesis
Year: 2008
Downloads: 54
Quote: 0
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Abstract


Because of the existing problems of contrast agent for X-ray computed tomography employed nowadays, Bi2 S3 was found to be a new contrast agent, which could raise the exactitude of the CT and achieve the forepart diagnosis for some serious diseases.Poly(amide amine)(PAMAM) dendrimer is a new class of macromolecule that emanates from a central core and has a defined number of terminal groups and interior cavity. In this thesis, PAMAM was used as the template to prepare PAMAM/Bi 2 S3 nanoparticles.The 6.0G PAMAM were synthesized by divergent synthesis using ethylenediamine as a raw material by means of Mickeal addition reaction and amidation reaction with methyl acrylate and ethylenediamine. The dendrimers were characterized by TEM and IR. The size of the prepared PAMAM was not homogeneous, so the products were dialyzed against water to remove dendrimers of low generation as well as some small molecules. In this study, also the modification of dendrimer was investigated and identified by IR spectra.PAMAM/Bi 2 S3 nanoparticles were synthesized by using bismuth nitrate as a bismuth precursor and sodium sulfide as a sulfur source in the presence of PAMAM dendrimers in water. The prepared nanoparticles were characterized by UV-Vis spectra and TEM. It demonstrated that PAMAM dendrimers with terminal amine groups and ammonium bismuth citrate were not fit for preparing the nanoparticles. TEM images of PAMAM/Bi2S3 nanoparticles indicated the role of PAMAM dendrimer as template. It also can be seen that the colour of the PAMAM/Bi2S3 nanoparticles turn light as time was prolonged, but when the products stored under N2 atmosphere or at low temperature the colour could keep for a while.The toxicity of 5.0G PAMAM, 5.5G PAMAM and 5.5G/Bi 2 S3 nanoparticles were also investigated and the results indicated that the toxicity of 5.5G PAMAM was less than that of 5.5G PAMAM. There was also no obvious difference of toxicity between 5.0G PAMAM dendrimer and 5.5G/Bi 2 S3 nanoparticles.

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