Dissertation > Excellent graduate degree dissertation topics show

Association of Single Nucleotide Polymorphisms in SCN5A and minK Gene with Atrial Fibrillation

Author: ZhangLin
Tutor: LiYaZuo
School: Third Military Medical University
Course: Epidemiology
Keywords: Atrial Fibrilation SCN5A Mink Single nucleotide polymorphism Relevance
CLC: R541.75
Type: Master's thesis
Year: 2010
Downloads: 13
Quote: 0
Read: Download Dissertation

Abstract


Atrial Fibrillation (AF) remains a major health problem in many regions around the world. The AF is the most common arrhythmia with multi-factorial pathogenesis. A number of studies of genetic epidemiology have assessed the association of KCNQ1、KCNH2 SNPs in potassium ion channel with AF in different populations. However, few studies assessed the association sodium ion channel SNPs with AF. Mutations in the human cardiac sodium channel gene have been previously discovered in a spectrum of cardiac rhythm disorders, such as, long QT intenal syndrome,Brugadasynd,idiopathic ventrieular fibrilltion duction system disease, and sick sinus syndrome.A number of studies of genetic epidemiology have assessed the association of potassium ion channels gene with AF in different populations. However, the results are inconsistent and inconclusive. We performed a meta-analysis of the association between G112A polymorphisms of Mink gene and AF.Objective1. To investigate associations of 4 SNPs, rs6793943、rs 1805125、rs41312391、rs6599230 in SCN5A gene with AF in Chinese Han population.2. To systematic review the association between G112A polymorphisms of Mink gene, to estimate the magnitude of the gene effects.Method1. A 1:1 case-control study was carried out. SNP Genotypes was detected by SNPstream Genotyping System. A logistic regression model was used to analyze the association of SNPs with AF in all subjects and in subgroups.2. Systematic review and meta-analysis were performed to analyze the association between G112A polymorphisms in Mink gene and AF.ResultThe genotypes of rs6599230 were found to be significantly associated with AF risk (p=0.025). AA genotype (homozygous minor allele) carriers had higher risk for AF compared with GG (OR=4; 95%CI,1.37-11.64;p=0.011). We did not find significant associations of other three SNPs.In subgroup analysis, male population had higher risk for AF compared with GG (OR=12.7; 95%CI, 1.50-107.94 ;p=0.019). In female population, no significant SNP was found.2. In the meta analysis, six case-control studies with a combined 841 cases and 1079 controls were summarized for minK gene G112A. Subgroups in different races were separately analyzed. Heterogeneity and publication bias were also explored. When all groups were pooled, the individuals with G allele had a 41% higher risk of AF compared with individuals with the A allele. The GG genotype (veruse CC genotype) was found to be significant association with increased AF risk. The significant associations of AF with genotypes were also found in both dominant and recessive genetic model. In subgroup analysis, the results were consistent with above, except that the pooled OR from Chinese population was not significant in recessive genetic model.Conclusion1. Our case-control study indicated that rs6599230 may be significantly associated AF in Chinese Han population.2. Our meta-analysis suggests there may be an important effect of G112A polymorphisms in Mink gene on the pathogenesis of AF.

Related Dissertations

  1. Research of Multiple Emails Automatic Summarization,TP391.1
  2. Application of Q-Learning in the Content-Based Image Retrieval Technology,TP391.41
  3. Research on Transductive Support Vector Machine and Its Application in Image Retrieval,TP391.41
  4. Establishment and Update of Similar Users’ Cluster in Personalized Information Retrieval,TP391.3
  5. Research on Query Expansion Technique of Retrieval System in Biomedical Field,TP391.3
  6. Studieson Effects of Soybean Species on Yuba and Initial Establishment of Quality Evalution System for Yuba,TS214.2
  7. Study on Genetic Variation and Its Effects and Expression of CFL2 Gene in Chickens,S831
  8. Epidemiological Investigation of Brucellosis in Livestock and Molecule Typing of Brucella Based on Single Nucleotide Polymorphism (SNP) Analysis,S855.12
  9. Sensation Seeking and Event-related Potentials CNV (Contingent Negative Variation) Study in Adolescents with Internet Game Addiction,R749.99
  10. The Analysis of Parent-child Relationship Impacting on Youth Internet Addiction and Design of Play Therapy Strategy,D669.5
  11. On the Trnslaion of Associative Meanings of Culturally-loaded Works by Applying Relevance-Adaptation Model,H315.9
  12. Contrastive Studies of Pun in Figures of Speech,H15
  13. DAPK1 Genetic Variations and Risk of Late-onset Alzheimer’s Disease,R749.16
  14. A Study on the Association of Four Single Nucleotide Polymorphisms (SNP) in Chromosome 4 with High Myopia,R778.11
  15. Information Disclosure Quality Rating and the Value Relevance of Financial Statements Data,F832.51;F224
  16. The E-cadherin Promoter-160 C/A Polymorphism and Nasopharyngeal Carcinoma in a Chinese Population,R739.63
  17. Perspective of Relevance Theory Advertising Translation validity analysis,H315.9
  18. Relevance Theory Study of military term semantic generalization,H030
  19. Omitted phenomenon in the Sino-Japanese Subtitles Translation from the Perspective of Relevance Theory,H36
  20. Apple Brown Spot of Hhyperspectral Remote Sensing Estimation Study,S436.611

CLC: > Medicine, health > Internal Medicine > Heart, blood vessels ( circulatory ) disease > Heart disease > Arrhythmia > Atrial fibrillation and atrial flutter
© 2012 www.DissertationTopic.Net  Mobile