Dissertation > Excellent graduate degree dissertation topics show

The Preparation and Effects Study of Targeting Drugs for Breast Cancer

Author: HanZhiXing
Tutor: ShiWei
School: Jilin University
Course: Biochemistry and Molecular Biology
Keywords: taxol breast cancer Targeting drugs HLA-G
CLC: R737.9
Type: Master's thesis
Year: 2009
Downloads: 143
Quote: 0
Read: Download Dissertation

Abstract


For the tumor clinical treatment, we advanced a new drug delivery method to breast cancer cells with the nanoparticle produced by targeted HLA-G Ab and liposomes. We focus on two aspects as follow: First, targeting anti-breast cancer drug synthesis; Second, the initial detection of synthetic products. We summarized some data and analyzed some problems for this project.In this paper, the HLA-G antibody is as the target-oriented drug agents to achieve targeted delivery of drugs and drug-rich areas to the lesions, which could combine to HLA-G antigen on the surface of breast cancer cell, thus to reduce the side effects of drugs to improve drug utilization. Liposomes is selected as a drug nano-carrier, because of the advantages of liposomes, such as reducing drug doses toxicity, allergy and immune response, releasing slowly drugs, changing the distribution of drugs in vivo and targetting releasing drugs.To link the antibody to liposomes that carry drugs, SPDP is used as a linked bridge. The amino groups of antibody and the amino groups of liposomes are linked together by disulfide bond.As a result, in the process of drug synthesis, the efficiency of synthesizing PE-PDP is more than 80%; the sizes of taxol liposomes is in the nanometer level, in line with the idea before the experiment; entrapment rate of taxol liposomes is 55%. The valence of synthetic products is 50% as much as 50% valence of the antibody.

Related Dissertations

  1. The Effects of Pu-erh Tea on Prevetion and Treatment of Tumor,R285.5
  2. Research on Web-Based Simulation Interoperability Testing Tool,TP391.9
  3. The Roles of Microtubules and Protein Phosphatase AtPP2CA in Regulation of Stomatal Movement in Arabidopsis Thaliana,Q945
  4. The Related Study of Breast-conserving Surgery Plus Postoperative Tangential Irradiation,R737.9
  5. The Relevance Research between Breast Cancer Calcification X Performance and Pathology,R737.9
  6. Influences of Different Health Status on the Clinical Laboratory Paramaters and Their Correlations with the HLA-DQB1,R346
  7. Comparative Analysis on CTF and CEF Regimens as Postoperative Adjuvant Chemotherapy in the Treatment of Phase Ⅱ Breast Cancer,R737.9
  8. Correlation of Humulus Pollen Allergic Rhinitis with HLA-DQA1 Gene,R765.21
  9. The Correlation of Ultrasound Elasticity with the Expressions of Estrogen Receptor, Progestron Receptor, C-erbB-2 in Breast Cancer,R445.1
  10. Expressions of HOXA9 HOXA10 and HOXA11 in Breast Cancer,R737.9
  11. The Feasibility of the Immunohistochemistry Classification to Predicting Prognosis in Breast Cancer,R737.9
  12. The Experimental Study of Antiangiogenic and Induction of Apoptosis by Maximum Tolerated Dose Combined with Low-dose Cyclophosphamide in Breast Cancer,R737.9
  13. Maximum Tolerated Dose Combined with Metronomic Chemoterpy on Proliferation and Angiogenesis in Treatment of Breast Cancer,R737.9
  14. The Expression and Significance of Parathyroid Hormone-related Protein in Human Breast Cancer with Skeletal Metastases,R737.9
  15. The Shrink Pattern of Breast Cancer After Neoadjuvant Chemotherapy and the Correlation with Partial Clinic Pathological Factors: Preliminary Results of a Plot Study,R737.9
  16. Analysis of Clinial and Patholgoic Characteristics between the Han and the Uygur Patients with Triple-negative Breast Cancer,R737.9
  17. Clinical Signifinance of Combined Detection of Tumor Markers in Breast Cancer,R737.9
  18. Septic lung injury (ALI / ARDS) in patients with peripheral immune parameters Th1, Th2, HLA-DR and Treg changes and Integrative Medicine,R459.7
  19. Isoflavone intake and the risk of breast and prostate cancer Meta-analysis,R737.25
  20. Mammographic X-ray analysis of false-negative breast cancer,R737.9
  21. Epidermal growth factor in breast carcinoma and its clinical significance 1,2,R737.9

CLC: > Medicine, health > Oncology > Genitourinary tumors > Breast tumor
© 2012 www.DissertationTopic.Net  Mobile