Dissertation > Excellent graduate degree dissertation topics show

Study on the Correlation Between the Levels of Il-18, IL-33 and Other Inflammatory Factors and Pulmonary Function in Different Stages of Asthma

Author: ZhangXiaoLin
Tutor: WangZuo
School: Dalian Medical University
Course: Internal Medicine
Keywords: interleukin(IL)-18 interleukin(IL)-33 bronchial asthma pulmonary function test
CLC: R562.25
Type: Master's thesis
Year: 2011
Downloads: 7
Quote: 0
Read: Download Dissertation

Abstract


Objective: To investigate the levels of some inflammatory factors including interleukin(IL)-18, interleukin(IL)-33, eosinophils(EOS), immunoglobulin(Ig)E, interferon(IFN)-γ, high sensitive C-reactive protein(hs-CRP) and pulmonary function in bronchial asthma patients. Study on the correlation between the level of those factors and the level of pulmonary function,and analyze the role of IL-18 and IL-33 in clinical diagnosis.Methods: The blood samples and clinical data from the 45 asthma patients in acute attack period and in remission period were collected. The serum levels of IL-18, IL-33, IgE, IFN-γwere detected by the method of ELISA. Also the data of the blood routine test and high sensitivity C-reactive protein were collected. While the blood samples of 25 healthy non-asthmas people were also collected to study as a control group. All patients were taken pulmonary function tests before and after glucocorticoid treatment to determine the level of FEV1, FEV1%pre, FEV1/FVC%, FEF50%pre, FEF75%pre, FEF25-75%pre and Raw%pre. Correlation between the inflammatory factors such as IL-18 and IL-33 and lung function were analyzed as well.Results:The results in our study were as below: first, the level of serum IL-18 in asthma patients was significantly higher than that in control group(P<0.05), and the level of serum IL-18 in acute asthmatic attack period was significantly higher than that in remission period (P<0.05); second, the levels of serum IL-33 and IgE in acute asthmatic attack period were significantly higher than those in control group(P<0.05), and the level of serum IL-33 in acute asthmatic attack period was significantly higher than that in remission period (P<0.05); third, the levels of serum hs-CRP in patients with acute asthmatic attack period was significantly higher than that in control group(P<0.05); fourth, the levels of serum IL-18, IL-33, IgE, EOS,EOS%, hs-CRP in asthmatic patients were positive correlation; fifth, the pulmonary function indicated that the levels of FEV1, FEV1%pre, FEV1/FVC%, FEF50%pre, FEF75%pre and FEF25-75%pre in acute asthmatic attack period was significantly higher than that in remission period (P<0.05); and the levels of FEV1 and other pulmonary function index in patients after glucocorticoid treatment were significantly higher than pretreatment(P<0.05), whereas the level of Raw%pre decreased significantly than pretreatment(P<0.05); sixth, the prominent negative correlations were seen between the levels of IL-18, IL-33 and the level of FEV1%pre both in acute asthmatic attack period and in remission period; meanwhile, there were significant difference of the levels of IL-18 and IL-33 in mild group, moderate group and severe group of pulmonary function; and there were distinct negative correlations between the levels of IgE, hs-CRP, eosinophils and the level of FEV1%pre.Conclusions: IL-18 and IL-33 are related to the pathogenesis of asthma. And distinct correlations exist between the levels of IL-18, IL-33 and pulmonary function in asthma patients. Thus, these inflammatory factors could be used to effectively evaluate the severity of asthma.

Related Dissertations

  1. The Influence of Early Intervention of Vitamina Combined with Mycobacterium Bovis Bacillus Calmette-Guerin on Lung CD11C+ and Anti-OVA Special IgE Expression in Adult SD Mice Asthma Model,R562.25
  2. The Influence in Different Route of Medication with Vitamin A on CD4~+CD25~+ Regulatory T Cell and Cell Factor of IL-4、 IFN-γ in a Rat Persistent Asthma Model,R562.25
  3. Glucocorticoid treatment of bronchial asthma patients serum IL-18, IL-33 levels in,R562.25
  4. Bronchial asthma serum interleukin -16 Determination and clinical significance,R725.6
  5. The Experimental Study Intervention Mechanisms of Breviscapine on the Airway Remodeling in Asthmatic Rats,R285.5
  6. On Professor Xu Yanling Chinese medicine treatment of bronchial asthma clinical experience,R249
  7. The Evidence-based Evaluation of RCT Literatures on Treating Bronchial Asthma with Point Application,R244.9
  8. Clinical Observation in the Patients with Asthma and Rhinitis Use the Way of Upper and Lower Airway Treatment.,R765.21
  9. Investigation on the Compliance of Inhaled Corticosteroid Treatment in Children with Bronchial Asthma in Meizhou,R725.6
  10. Therapeutic Observation on Piqixu Syndrome of Children’s Bronchial Asthma in Catabasis Treated with Gu Ben Fang Xiao Yin,R272
  11. Inhibiting activation of PBMCs Dex and TP expression IL-4, IL-5 and IL-13 Mechanism,R562.25
  12. A Study on the Relationship between CD4~+ CD25~+ T Regulatory Cell and Immune Tolerance in Lymph in Bronchial Asthmatic Rat,R562.25
  13. FIZZ1 induced airway epithelial - mesenchymal transition lead to airway remodeling in asthma early,R562.25
  14. Bronchial airway smooth muscle cells mitochondrial ATP-sensitive potassium channels on PKC signal transduction pathways and cell proliferation,R562.25
  15. The Clinical Study of Qidong Yifei Soup in Treating Remission Stage of Bronchial Asthma,R256.12
  16. Thenar points acupuncture treatment of acute bronchial asthma clinical research,R246
  17. Phosphatidylinositol 3-kinase with Simple Acute Exacerbation of Bronchial Asthma, Chills and Fever Asthma Study on the Correlation,R259
  18. Whooping -speed flat sheet heat treatment of bronchial asthma exacerbations Asthma Clinical Research,R259
  19. Effect of Bacillus Calmette-Guérin on the Expression of PPAR-γ in the Lung Tissue of Asthmatic Mice and Its Significance,R562.25
  20. Toll-like Receptors 4 and Other Related Signal Molecules on the Synthesis and Secretion Function and Cells Proliferation of Asthma Human Airway Smooth Muscle,R562.25

CLC: > Medicine, health > Internal Medicine > Respiratory system and chest diseases > Trachea and bronchial disease > Bronchial disease > Bronchial asthma
© 2012 www.DissertationTopic.Net  Mobile