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Clinical Research of Autologous Bone Marrow Stem Cell Transplantation for Treatment of Decompensated in Cirrhosis

Author: HouYue
Tutor: GuoXiaoZhong
School: Dalian Medical University
Course: Internal Medicine
Keywords: Liver cirrhosis Autologous bone marrow stem cells Transplantation
CLC: R575.2
Type: Master's thesis
Year: 2011
Downloads: 6
Quote: 0
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Abstract


Objective: To study the clinical effect of autologous bone marrow stem cell transplantation via hepatic artery in treamtment of decompensated cirrhosis.Methods: Eighty patients with decompensated cirrhosis were included. Among them, 36 patients were female, 50 patients were male, they aged 26 to 75 years old, mean age was 51±11 years old, 55 patients were posthepatitic cirrhosis, 25 patients were alcoholic cirrhosis, 1 patient was schistosomiasis cirrhosis, 3 patients were autoimmune liver disease, and 2 patients were drug-induced liver cirrhosis. A total of 180~200 ml bone marrow was aspirated from poster superior spine in aseptic conditions. After isolation and purification, the stem cells were transplanted into the liver via hepatic artery. After transplantation, clinical symptoms and signs, laboratory data and side effects were recorded at the 2, 4 and 8 weeks.Results: After transplantation in 2,4 and 8 weeks, levels of albumin was increased(P<0.01) from 32.90±5.50g / L to 38.65±6.67g / L. Alanine aminotransferase was decreased(P<0.01) from 86.08±33.44U / L to 72.06±10.10U / L. Aspartate aminotransferase was decreased(P<0.05) from 70.73±44.12U / L to 58.63±21.61U / L. Prothrombin time was decreased (P<0.01) from 16.60±3.69s to 15.05±2.64s. Fibrinogen was increased (P<0.01) from 2.24±0.84 g / L to 2.65±0.83 g / L. Total bilirubin level was decreased, but no significant difference was found. After stem cell transplantation, the majority of clinical symptoms were improved. In 86 cases of transplant patients, serious side effects were not found.Conclusion: After transplantation of autologous bone marrow, the liver function and general well-being of patients were significantly improved. This method was safe and effective in the treatment of patients with decopensated cirrhosis.

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CLC: > Medicine, health > Internal Medicine > Digestive and abdominal diseases > Liver and gall bladder disease > Cirrhosis
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