Dissertation > Excellent graduate degree dissertation topics show

Clinical Research of Autologous Bone Marrow Stem Cell Transplantation for Treatment of Decompensated in Cirrhosis

Author: HouYue
Tutor: GuoXiaoZhong
School: Dalian Medical University
Course: Internal Medicine
Keywords: Liver cirrhosis Autologous bone marrow stem cells Transplantation
CLC: R575.2
Type: Master's thesis
Year: 2011
Downloads: 6
Quote: 0
Read: Download Dissertation


Objective: To study the clinical effect of autologous bone marrow stem cell transplantation via hepatic artery in treamtment of decompensated cirrhosis.Methods: Eighty patients with decompensated cirrhosis were included. Among them, 36 patients were female, 50 patients were male, they aged 26 to 75 years old, mean age was 51±11 years old, 55 patients were posthepatitic cirrhosis, 25 patients were alcoholic cirrhosis, 1 patient was schistosomiasis cirrhosis, 3 patients were autoimmune liver disease, and 2 patients were drug-induced liver cirrhosis. A total of 180~200 ml bone marrow was aspirated from poster superior spine in aseptic conditions. After isolation and purification, the stem cells were transplanted into the liver via hepatic artery. After transplantation, clinical symptoms and signs, laboratory data and side effects were recorded at the 2, 4 and 8 weeks.Results: After transplantation in 2,4 and 8 weeks, levels of albumin was increased(P<0.01) from 32.90±5.50g / L to 38.65±6.67g / L. Alanine aminotransferase was decreased(P<0.01) from 86.08±33.44U / L to 72.06±10.10U / L. Aspartate aminotransferase was decreased(P<0.05) from 70.73±44.12U / L to 58.63±21.61U / L. Prothrombin time was decreased (P<0.01) from 16.60±3.69s to 15.05±2.64s. Fibrinogen was increased (P<0.01) from 2.24±0.84 g / L to 2.65±0.83 g / L. Total bilirubin level was decreased, but no significant difference was found. After stem cell transplantation, the majority of clinical symptoms were improved. In 86 cases of transplant patients, serious side effects were not found.Conclusion: After transplantation of autologous bone marrow, the liver function and general well-being of patients were significantly improved. This method was safe and effective in the treatment of patients with decopensated cirrhosis.

Related Dissertations

  1. Study of Intracerebral Transplantation of Umbilical Cord Blood Mesenchymal Stem Cells in a 6-Hydropamine Rat Model of Pakinson’s Disease,R742.5
  2. A Model of Acute Interstitial Pneumonitis by Murine Cytomegalovirus Infection in Mice with Allogenic Skin Transplantation,R-332
  3. The Study of Immuno-tolerance Mechanism of the Third-party Bone Marrow-derived Mesenchymal Stem Cells on Allogenic Transplantation,R392
  4. Clinical Research of Autologous Bone Marrow Stem Cell Transplantation on Liver Cirrhosis Induced by Hepatitis B,R575.2
  5. The Effect of Exogenous Brain-derived Neurotrophic Factor on Transplantation Treatment of Bone Mesenchymal Stem Cells in Intracerebral Hemorrhage in Adult Rats,R743.34
  6. Evaluation the Improvement of Cardiac Function with Myocardial Infarction Transplanted into Autologous Bone Mesenchymal Stem Cells from Different Ways by Ultrasound,R542.22
  7. Relationship and Significance of Gene Transcription Profiles in Rat Liver Regeneration and Liver Cirrhosis Occurrence,R575.2
  8. Study on Human Peripheral Blood Stem Cells Differentiate into Liver Cells,R575.1
  9. Clinical Research of Autologous Transplantation of Bone Marrow Stem Cells on Decompensate Cirrhosis Patients,R575.2
  10. Preliminary Study on Angiogenesis in Ischemic Hindlimb of Diabetic Rat Model after Mesenchymal Stem Cell Implantation,R587.1
  11. Nerve and Peripheral Vascular Grafts with a Long Section of the Line Repair Nerve Damage in Research,R651.3
  12. Experimental Investigation of Grafting Pathways of Bone Marrow Stromal Cells into Spinal Cord Injury in Rats.,R651.2
  13. Improvement of the Result of Autologous Fat Transplantation in Facial Recontouring Surgery by Using "Cocktail" Therapy,R622
  14. Clinical Effect of Autologous Fat Pellet Particle Transplanting Combined Ligustrazine on Breast Augmentation,R622
  15. Analysis of the Risk Factors Influencing the Morbidity and the Prognosis of Hepatic Encephalopathy,R747.9
  16. Autologous bone marrow stem cell transplantation in the treatment of heart failure after myocardial infarction term efficacy,R542.22
  17. PSE lamivudine hepatitis B cirrhosis and portal hypertension clinical observation,R575.2
  18. Swelling commonly used lidocaine and epinephrine on fat cell activity,R622
  19. Bone marrow mesenchymal stem cells in the same kind of heart transplantation on Treg cells in rats,R654.2
  20. Function Test and Application of Human Fetal Hepatocyte Line L-02,R657.3

CLC: > Medicine, health > Internal Medicine > Digestive and abdominal diseases > Liver and gall bladder disease > Cirrhosis
© 2012 www.DissertationTopic.Net  Mobile