Dissertation > Excellent graduate degree dissertation topics show

Preliminary study of Pueraria tablet preparation process and quality standards

Author: LiXuZhou
Tutor: HanLiZuo
School: Beijing University of Traditional Chinese Medicine
Course: Chinese medicine
Keywords: Gegentang Tablet Macroporous resin Pharmaceutical technology Quality standard
CLC: TQ461
Type: Master's thesis
Year: 2009
Downloads: 281
Quote: 2
Read: Download Dissertation

Abstract


Objective:To study the extraction and tablet process of Gegentang,prepare a Gegentang Tablet with small dose,and establish its initial quality standards.Methods:(1) In accordance with the role of every Chinese herbal in Gegentang, its active ingredient or total ingredient as index,single factor investigation and orthogonal design was used to optimization the extracting process with water and purifying process with macroporous resin of Gegen,Baishao,Mahuang,Gancao, Dazao;orthogonal design was used to optimization the extracting process of Guizhi and Shengjiang’s volatile oil by steam distillation.(2) Single factor investigation was used to select the tablet excipients commonly used,and then prepare the gross tablet of Gegentang.(3) To establish the initial quality standards of Gegentang Tablet,including identification means of ervery Chinese herbal in Gegentang by TLC and determination means of Puerarin and Ephedrine in Gegentang Tablet.Results:(1) The best process condition of Gegen,Baishao,Mahuang,Gancao, Dazao extracting with water and purifying with macroporous resin was optimized, and the best process condition of Guizhi and Shengjiang’s volatile oil extracting by steam distillation was optimized.After purified,the paste-forming rate was respectively reduced,which is good for the preparation of table upcoming.(2)The tablet process of Gegentang Tablet was identified,tablet prepared weighs 0.6g every tablet,and its dose was 2 times a day for each two,which greatly reducing the dose.Essential achieved the desired purpose of the experiment.(3) The identification means of ervery Chinese herbal excetpt Dazao in Gegentang by TLC and the determination means of Puerarin and Ephedrine in a same HPLC condition were established,which were feasible and stable.Each Gegentang Tablet containing Puerarin 75.20 mg and ephedrine 32.70 mg.Referencing the limited content in Pharmacopoeia,the initial content standard of Gegentang Tablet was each tablet containing Puerarin more than 48.1 mg and ephedrine moer than 23.2 mg.Conclusion:The extracting and purifying process of Gegentang Tablet was feasible,the tablet prepared had a small dose,and its quality controlling means was stable and reliable.The desired experiment aim of this study was essential achieved.

Related Dissertations

  1. Studies Preparation of Procyanidines from Grape Seeds and Mycotoxins Determination,TQ461
  2. Soy Germ Isoflavone Conversion by Lactic Acid Bacteria and Development on Its Chewing Tablet,TS214.2
  3. Studies on Quality and Manufacturing Process of Candesartan Cilexetil Tablet,TQ463.2
  4. Adsorption Performance of CO2 on Different Spherical Porous Materials,X51
  5. Strength Analysis and Investigation about Laminated Structures Based on Numerical Method,O342
  6. The Cai Tony tablets in the treatment of experimental autoimmune thyroiditis,R285
  7. Studies on Preparation Technology, Quality Standard and Preliminary Pharmacodynamic of Qixian Granules,R285
  8. Study on the Quality Standard of Longhui Pills,R286
  9. Baiyangdian analysis of organic pollutants in water,X832
  10. Adsorptive Removal of Bad Flavor Compounds in Anchovy Enzymatic Hydrolysates,TS254.4
  11. Study on the Preparation and the Quality Standards of the Wuhuo Depressurization Dripping Pills,TQ461
  12. Isolation and purification of the ingredients of olive polyphenols such as tyrosol,TQ351.0
  13. Study on Processing Technology of the Microencapsulated Heme-chip,TQ464.5
  14. Studies on the Extraction and Purification of Flavonoids in Tussilago Farfara L.,TQ461
  15. Technology of Flavonoids Extraction in Lingwu Long Date and Evaluation of Its Antioxidizing Activity,S665.1
  16. Racecadotril metabolite (Tiorphan) blood concentration and application,R96
  17. Discard tobacco extract was purified solanesol research,R91
  18. Compound Danning tablet with surgery Clinical observation of bile duct stones,R657.4
  19. Comparison about Internal Quality of Compound Danshen Tables from Different Pharmaceutical Factories,R286.0
  20. Study on the Pharmacy of QiJiao Tablet,R286
  21. Welding Stress and Deformation Analysis of Leg Racks of Marine Petroleum Platform Using Thermal Elastic-Plastic Finite Element Method,TG404

CLC: > Industrial Technology > Chemical Industry > Pharmaceutical chemical industry > The Chinese herbal medicine preparations of the production
© 2012 www.DissertationTopic.Net  Mobile