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Objective: To investigate PTTG, OPN and bFGF in cervical squamous cell carcinoma and its clinical significance. Methods: Immunohistochemical SP method detected 28 cases of normal cervical epithelium (NEC), 36 cases of cervical intraepithelial neoplasia (CIN) and 68 cases of cervical squamous cell carcinoma (SCC) tissue PTTG, OPN, bFGF, CD34 and Ki-67 expression explore PTTG, OPN and bFGF in the SCC group and microvessel density (MVD), cell proliferation index (PI), invasion, metastasis and prognosis. RESULTS: From NCE to CIN and then to SCC group, PTTG expression was significantly increased (P lt; 0.01). PTTG expression in the SCC group, respectively, and FIGO stage, pelvic lymph node metastasis, depth of stromal invasion and vascular infiltration (P lt; 0.05). FIGO staging of cervical squamous cell carcinoma Ⅱ, with pelvic lymph node metastasis, invasion and stroma breakthroughs have vascular invasion, their PTTG expression was significantly higher than FIGO stage Ⅰ, without pelvic lymph node metastasis, depth of invasion in the superficial muscle interstitial layer within and without vascular invasion (P lt; 0.05). PTTG expression was higher in the CIN group was significantly higher than the low expression of PI, but did not reach statistical difference (P = 0.053). PTTG expression in the SCC group, respectively, and PI, MVD and survival independent of (P gt; 0.05). OPN expression in the NCE with CIN group had no significant difference (P gt; 0.05), while in the SCC group was significantly higher (P lt; 0.01). OPN expression in the SCC group, respectively, and FIGO stage and vascular infiltration, cervical cancer FIGO stage Ⅱ, and there is vascular invasion, their expression of OPN were significantly higher than FIGO stage Ⅰ and no vascular invasion (P lt; 0.05). OPN expression in the SCC group PI significantly correlated (r = 0.422, P = 0.000), respectively, and the survival rate has nothing to do with the MVD (P gt; 0.05). OPN expression of PTTG in the SCC group was no significant correlation (P gt; 0.05). CIN and then from NCE to SCC group, bFGF expression was significantly increased (P lt; 0.01). bFGF expression in the SCC group, whether pelvic lymph node metastasis and vascular infiltration, cervical squamous cell carcinoma with pelvic lymph node metastasis and vascular invasion, their expression of bFGF was significantly higher than those without pelvic lymph node metastasis and without vascular invasion (P lt; 0.05). bFGF and MVD in the SCC group a significant positive correlation (r = 0.326, P = 0.007), respectively, and the survival rate has nothing to do with the PI (P gt; 0.05). bFGF expression of OPN in the SCC group, a significant positive correlation (r = 0.259, P = 0.016), with no significant correlation between PTTG (r = 0.153, P = 0.212). Conclusion: PTTG, OPN and bFGF overexpression may be involved in the occurrence of cervical squamous cell carcinoma and metastasis. OPN overexpression of PTTG and may contribute to cervical intraepithelial neoplasia and cancer cell proliferation, bFGF overexpression may promote tumor angiogenesis. PTTG, OPN and bFGF overexpression may promote invasion and metastasis of cervical squamous cell carcinoma. Detection of cervical squamous cell carcinoma PTTG, OPN and bFGF expression in furthering the understanding of cervical squamous cell biological behavior and prognosis of certain reference value.
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