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Background In the United States , the incidence of prostate cancer among the first in the all male cancer patients , mortality after lung cancer . Asian Chinese among prostate cancer incidence is very low . However , due to the lack of early screening for this disease , the diagnosis most patients have been transferred . Recently, a series of studies have shown that some ordinary chromosome variation was found to be associated with prostate cancer . Region on chromosome 7 7 SNP rs1447295 8q24 , 17q rs4430796 , rs6983267 8q24 , 2p15 rs16901979 8q24 , rs7210482 , rs1859962 17q , rs5945572 Xp11.22 ( 3 8q24 , 17q12 , 17q24.3 , Xp11.22 , 2p15 each a ) has been shown to be associated with prostate cancer . However , these SNP with prostate cancer in the Chinese population has the correlation has not yet been confirmed . Therefore , the main purpose of this study is to verify the relevance of these SNP with prostate cancer in the Chinese population . In the southern Chinese population ( 99 prostate cancer population and 99 age-matched control subjects ) detected seven SNPs in the region on chromosome 7 , and evaluate their role associated with prostate cancer in the Chinese population . Results rs1447295 8q24 , rs4430796 17q 8q24 rs6983267 , rs7210482 2p15 prostate cancer associated with statistically significant [ odds ratio ( OR ), 1.684 ; 95 % confidence interval ( 95% CI ) , 1.002-2.830 ] , [ odds ratio ( OR ) , 0.594 ; 95% confidence interval ( 95% CI ) , 0.364-0.969 ] , [ odds ratio (OR) , 1.597 ; 95 % confidence interval ( 95% CI ) , 1.008-2.531 ] , [ odds ratio (OR ) , 2.622 ; 95% confidence interval ( 95% CI ) , 1.051-6.524 ] (P lt; 0.05) . rs16901979 8q24, rs1859962 17q, rs5945572 Xp11.22 with prostate cancer was significantly associated ( P gt ; 0.05) . Conclusion We believe Rs1447295 8q24, rs4430796 17q, rs6983267 8q24, rs7210482 2p15 with prostate cancer in the Chinese population have some relevance .
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