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Objective: To observe the different levels of low central venous pressure on the liver vein injury animal models hemodynamic change the influence of the amount of bleeding and hepatic venous injury, looking for the LCVP best security value. 32 Methods: Guangxi Bama miniature pigs were randomly divided into five groups (n = 6): A group, CVP 0mmHg; B group, CVP 1mmHg; C group, CVP of 2 mmHg; D group, CVP 3mmHg; Group E, CVP 4mmHg. All animals anesthetized cut left femoral artery catheter for continuous monitoring of arterial blood pressure. Right internal jugular vein cut placed in a single chamber deep venous catheter for continuous monitoring of CVP. The right femoral vein incision placement floating 7FrSwan-Ganz catheter for monitoring CO and pulmonary artery pressure. Laparotomy removal of part of the left hepatic lobe, left hepatic vein was isolated, floating catheter placed in the outer sheath, catheter depth of about 3cm production of hepatic vein injury animal model for the amount of bleeding in the unit of time observing the different levels LCVP. The above model to establish good, after the the floating catheter with temperature dilution method measuring cardiac blood (CO) to record heart rate (HR), mean arterial pressure (MAP), mean pulmonary artery pressure (MPAP), pulmonary capillary wedge pressure (PCWP) HP monitor cardiac index (CI), systemic vascular resistance (SVR), pulmonary vascular resistance (PVR) hemodynamic parameters. Each animal infusion different doses of nitroglycerin, the CVP control values ??in each group set CVP. Established in each group CVP smooth after 10 minutes, re-recording and calculating the hemodynamic indicators and monitoring the hepatic venous pressure. Then the outer sheath tube opening placed in a axillary the midline level and open the left hepatic vein distal end of 30 seconds, collector measuring the amount of bleeding of the left hepatic vein. Results: 1. Different animal model of low central venous pressure to abandon the experiment a the 32 Bama miniature pig experiments endotracheal intubation failure death, floating catheter placement failure to abandon the experiment a success of anesthesia 30 cases of animal model molded rate of 94% and 100% of the rate of low central venous pressure animal model molded. Different low central venous pressure pig hemodynamic buck back and forth between the groups heart rate within the group and between groups showed no significant differences (P> 0.05). MAP, CO, CI, MPAP before in the buck among groups showed no significant difference (P> 0.05). Group A and group B buck MAP, CO, CI, MPAP was significantly lower than before the buck (P <0.05); C group, D group and E group MAP, CO, CI, MPAP the buck before and after the group was no obvious differences. The buck after group A and group B, MAP, CO, CI, MPAP was significantly lower than group C, D and E group (P <0.05). SVR, PVR buck before each group showed no significant difference (P> 0.05). Group A and group B decreased SVR, PVR was significantly higher than the buck before (P <0.05); SVR, PVR group before and after the step-down of the C group, D group and E group showed no significant difference. Group A and group B, SVR, PVR decreased significantly higher than in group C, group D and group E (P <0.05). PCWP buck before each group showed no significant difference (P> 0.05). PCWP lower than buck buck after the A, B and C groups (P <0.05); PCWP group before and after the group D and group E Buck was no significant difference. Group A, B and C groups buck PCWP was significantly lower than Group D and Group E (P <0.05). 3. Different the LCVP of the amount of bleeding of the hepatic vein injury affect central venous pressure and hepatic venous pressure into a positive linear correlation (r = 0.985, P <0.01), the amount of bleeding and central venous pressure into a positive linear correlation (r = 0.923, P < 0.01). Group A, group B, group C, group D and group E hepatic vein unit time, the amount of bleeding 8.5 ± 2.25ml/30s, 16.3 ± 2.06 ml/30s 24.5 ± 3.39ml/30s, 27.2 ± 3.25 ml/30s and 43.6 ± 6.62ml/30s, E Group D Group C group> B group> A group (P <0.05). Conclusion: controlled low central venous pressure on the body hemodynamic varying degrees of impact of LCVP can effectively reduce the amount of bleeding of the liver vein injury. To maintain a relatively stable hemodynamic situation, to minimize the amount of bleeding of Bama miniature pig liver vein injury the LCVP best range 2mmHg ~ 3mmHg.
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