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Cyclodextrin molecule resveratrol

Author: AnWeiJuan
Tutor: SuoRan
School: Agricultural University of Hebei
Course: Agricultural Products Processing and Storage
Keywords: Resveratrol Hydroxypropyl -β- cyclodextrin Inclusion Inclusion rate Phase solubility
CLC: R283
Type: Master's thesis
Year: 2009
Downloads: 366
Quote: 1
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Abstract


Resveratrol is a phytoalexin, it has anti-free radicals and reduce the role of the incidence of coronary heart disease. Recent studies have found that resveratrol in cancer initiation, promotion and expansion of three main stages are inhibited, is a potential anti-cancer drugs. However, due to low solubility in water, resveratrol, the isomerization under UV radiation, unstable, resulting in low bioavailability, its application is limited. Thus increasing the solubility and stability of resveratrol to the wider application of resveratrol has important significance. Cyclodextrins are a class of macrocyclic compounds truncated cone, its unique cage-like structure clathrate guest molecules can form inclusion complexes, when the guest molecules are included in the numerator or the guest molecules in the cavity of cyclodextrin molecule from between trimer. Meanwhile, cyclodextrin hydrophilic polyhydric outside, the formed inclusion complex has good wettability, so as to achieve the object of solubilizing insoluble results. α-, β-cyclodextrins are commonly used to solubilize the compounds. Since the low solubility of β-cyclodextrin itself, usually at its edges by introducing a modifying group to improve its solubility, to expand its scope of application. As the object of the more common solubilizing β-cyclodextrin derivative is hydroxypropyl-β-cyclodextrin, which has characteristics of low toxicity and good water-soluble. This paper studies the hydroxypropyl-β-cyclodextrin inclusion compound resveratrol, solubilization, main contents and results are as follows: (a) inclusion complex prepared by freeze drying by orthogonal experiment with inclusion Screening for inclusion compound rate of process conditions: Resveratrol: hydroxypropyl-β-cyclodextrin is 1:2 (molar ratio), inclusion temperature 30 ℃, inclusion time was 60 min. Inclusion rate by measuring the size of proof hydroxypropyl-β-cyclodextrin resveratrol better. (2) using UV-visible spectrophotometry, infrared spectrophotometry, differential scanning calorimetry, etc. carried out on the inclusion phase identification. The results showed that: Resveratrol - hydroxypropyl-β-cyclodextrin inclusion complex has been formed. (3) hydroxypropyl-β-cyclodextrin in alkaline medium is very stable, can be acid decomposition, so the use of hydrochloric acid method for inclusion were destroyed off the bag tests, the inclusion of resveratrol from release; measured by HPLC Resveratrol. The results showed that: inclusion with 0.1 mol / L hydrochloric acid for removal package is better. (4) were studied by phase solubility of hydroxypropyl-β-cyclodextrin inclusion of resveratrol and solubilization. The results showed that: in the absence of cyclodextrin, the solubility of resveratrol 0.0169 mg / mL. With the increase of cyclodextrin concentration, increasing the solubility of resveratrol. When a hydroxypropyl-β-cyclodextrin concentration of 15.83 mg / mL, the solubility of the original free resveratrol resveratrol 467.46 times the solubility. Resveratrol increased solubility on the one hand to further verify the resveratrol with hydroxypropyl-β-cyclodextrin inclusion complex, it also shows hydroxypropyl-β-cyclodextrin on resveratrol Solubilization of alcohols. (5) inclusion complex by comparing resveratrol and resveratrol in the UV irradiation trend can be seen, not only hydroxypropyl-β-cyclodextrin can increase the water solubility of resveratrol, also increase its UV stability.

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