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A Systematic Review of Chronic Hepatitis B

Author: ZhangTieFeng
Tutor: MengLingJun
School: Shandong University of Traditional Chinese Medicine
Course: Basic Theory of Traditional Chinese Medicine
Keywords: Chronic hepatitis B Heat dampness System Evaluation Evidence-Based Medicine
CLC: R259
Type: Master's thesis
Year: 2008
Downloads: 95
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Abstract

Objective: use of evidence-based medicine systematic reviews of clinical trials for the treatment of chronic hepatitis B in recent years, with heat dampness literature qualitative and quantitative analysis to provide the best evidence for clinical treatment, and determine the preliminary treatment of the disease advantage Recipe . Method: according to the search strategy retrieved literature, evaluate the quality of bibliographic retrieved from the CD-ROM database of biomedical literature, to retrieve the full text in Qinghua Fang Zhongwen Technology Journal Full-text database, not retrieved articles from Chongqing VIP Consulting Co., Ltd. Chinese Science and Technology journals To retrieve the full text of the full-text database by hand searching through electronic retrieval yet to be found in the literature and then the full text. Literature inclusion criteria for the randomized controlled heat dampness Chinese medicine treatment of chronic hepatitis B or quasi-randomized controlled clinical trials. Evaluation of evidence-based medicine evaluation method. The evaluation mainly include general quantitative and qualitative analysis of all the data included in the study, Meta-analysis of the quantitative analysis data. Results: Total heat dampness recipe and heat dampness Recipe joint bibliography of other drug treatment of chronic hepatitis B 1431, 236 literature design study with a randomized controlled trial, all the literature published in 135 kinds magazine. Finally, the 74 included studies, which selected the order to number two randomized literature (25-1), (25-2); randomized literature outpatient medical records odd and even serial number 1 (25-2); randomized single blind a grouping literature (1-4); literature grouped according to the order of admission 1 (1-59); literature grouped according to the random number table 2 (24-3) (26-1). A research report random occult. 18 reports in the literature follow-up, a study reported cases shedding a study using the intent-to-treat analysis. The overall results of the evaluation show that clearing heat and dampness randomized controlled clinical trials for the treatment of chronic hepatitis B information of lower methodological quality, most of the studies lack of diagnostic criteria or diagnostic criteria are not uniform, rarely used blinded adverse reactions observed less mentioned, the lack of long-term clinical effects and quality of life data, the credibility of the data processing, the design is still not perfect and rigorous. Conclusion: In the heat dampness medicine in the treatment of chronic hepatitis B clinical studies, randomized controlled trial design research programs growing by the year, a gradual increase of the quality of research, but the overall quality is lower and the level of clinical research trial design needs to be improved. Matrine treatment of chronic hepatitis B in terms of efficiency or antiviral effect was significantly better than the control group; Oxymatrine valid prescription for the treatment of chronic hepatitis B; Oxymatrine control interferon treatment of chronic B the Hepatitis neither significant nor clinically significant, but its efficacy is close to interferon. Single Recipe reported Chinese medicine group, the lack of research literature, still need clinical depth research.

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