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Objective: Pituitary adenomas are relatively common benign intracranial crowd incidence is generally one hundred thousandth, or about 10% of intracranial tumors, and prolactin (PRL) is a hormone-secreting pituitary adenoma tumor is the most common, accounting for the highest proportion of pituitary tumors, about 40% to 60%. Currently transsphenoidal pituitary tumor surgery is the most common and most effective method, but recurrence is still troubled by a neurosurgeon one of the issues. Before 2000, the World Health Organization (WHO) has been attributed to pituitary tumor classification of tumors of the central nervous system, the main emphasis of the immune phenotype, tumor histology and ultrastructure. This study of PRL pituitary adenoma patients before and after changes in hormone levels, hormone levels and explore the relationship between surgery, in order to better guide clinical diagnosis and treatment. Methods: A retrospective analysis of the First Affiliated Hospital of Dalian Medical University neurosurgeon from March 2002 to March 2010 among 128 cases of PRL pituitary adenoma patients with clinical data, treatment and follow-up results. Measurement of pituitary PRL adenoma before surgery, postoperative PRL levels, and other factors that may affect the outcome, such as gender, age, aggressive, with or without cystic degeneration and (or) stroke, surgical resection extent for statistical analysis. Results: The patients there were 21 cases of recurrence, the recurrence rate of 16.4%, time to recurrence after 10 months to 5 years, the average time to recurrence after 3.6 years. PRL pituitary adenoma after the impact of short-term efficacy of six relevant indicators for Logistic regression analysis results: PRL adenoma invasiveness, cystic degeneration and (or) stroke, extent of surgical resection and postoperative prolactinomas Recent significant effect phase (p lt; 0.05), PRL pituitary adenoma invasiveness and cystic degeneration and (or) stroke β value gt; 0, Exp (β) gt; 1, indicated that the two factors that can reduce surgery increase the risk of recurrence; perioperative cut β value lt; 0, Exp (β) lt; 1, indicating that the factors can improve surgical treatment, reducing the risk of recurrence, other factors such as preoperative hormone PRL levels, gender, age and postoperative term efficacy was no significant correlation (p gt; 0.05). Early postoperative PRL levels and PRL adenomas long-term efficacy of X2 test shows: both correlated (p lt; 0.001), postoperative PRL ≤ 20ng/ml patients with long-term improvement rate (98.1%) was significantly higher 20 ~ 40ng/ml (14.3%, p lt; 0.001) and gt; 40ng/ml patients (12.5%, p lt; 0.001), three groups have significant difference (χ ~ 2 = 76.910 p lt; 0.001), then no significant difference between the two groups (χ ~ 2 = 0 P = 1.00). Invasive adenomas, early postoperative PRL levels and postoperative recurrence Show: Non-invasive PRL adenoma recurrence rate was 0% (0/98), invasive PRL adenoma recurrence rate was 70.0% (21/30), early postoperative PRL ≤ 20ng/ml were non-invasive adenoma recurrence. Conclusion: prolactinomas surgery and invasive adenomas, cystic degeneration and (or) stroke, extent of surgical resection was significantly related; preoperative PRL levels and the effect of surgery was no significant correlation; early postoperative PRL levels and PRL gland Tumor term efficacy is closely related prolactinomas (non-invasive) to normal early postoperative PRL tumor cure can be determined; early postoperative PRL ≤ 20 ng / ml PRL adenomas as predictors of long-term remission; non-invasive of PRL adenomas can be cured completely by surgery.
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