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Objective : To observe the by- drink I number of malignant pleural effusion rat model of serum TNF - alpha and IL-4 , and to explore by drinking Ⅰ on the mechanism of action of MPE . Methods: Ehrlich ascites tumor ( EAC ) cell lines of malignant pleural effusion rat model , 60 Wistar rats were randomly divided into five groups , the blank group , model group , Chinese medicine group , DDP group , Chinese medicine plus DDP group , n = 12 only . Detected by ELISA in serum TNF - alpha and IL-4 content . Results: model group, group , DDP group and medicine plus DDP group , serum TNF - alpha content , significantly higher than the control group , a statistically significant difference ( p < 0.01 ) , traditional Chinese medicine group , DDP group , Chinese plus DDP group of TNF - alpha content lower than the model group , there is a significant difference ( p < 0.01 ) , TNF-alpha content of traditional Chinese medicine group and DDP group quite , no significant difference ( p > 0.05 ) , traditional Chinese medicine plus DDP group of of TNF - alpha were significantly lower than the Chinese medicine group and DDP group , a significant difference ( p < 0.01 ) . Model group, group , DDP group and medicine plus DDP group , serum IL - 4 content was significantly higher than the blank group , statistically significant difference ( p < 0.01 ) ; Chinese medicine group , DDP group , medicine plus DDP group of IL-4 content of less than model group , a significant difference ( p < 0.01 ) ; Chinese medicine group and DDP group IL-4 content quite , no significant difference ( p > 0.05 ) ; Chinese medicine plus DDP group of IL-4 content , significantly lower than the Chinese medicine group and DDP group , a significant difference ( p < 0.01 ) . Conclusions: 1. Ⅰ by drinking can significantly reduce the MPE serum TNF - alpha content . 2 by drinking Ⅰ can significantly reduce content of MPE serum IL-4 . 3 -by- drink I could by reducing the content of TNF - alpha and IL-4 and the role of prevention and treatment of MPE .
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