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Objective: psoriasis, also known as \The higher incidence of the disease is easy to relapse, longer course, particularly violations of young adults as much, a great impact on the patient's physical and mental. At home and abroad study the pathogenesis of psoriasis although it has made some achievements, but has yet to draw firm conclusions. In recent years, studies have shown that there are many exceptions, the immune function of patients with psoriasis. The data indicate that cellular immunity plays an important role in the pathogenesis of psoriasis patients. Tumor necrosis factor α (TNF-α) is a kind of cytokines having a wide range of biological activity, to participate in the regulation of inflammatory and immune response, with a variety of diseases such as cancer, infection, fever, endotoxic shock, autoimmune diseases, The transplant rejection diseases and development related. In addition, TNF-α has the inflammatory media role by promoting the synthesis and release of inflammatory cytokines, promote the expression of cell adhesion molecules, aggregation and adhesion of inflammatory cells, capillary dilatation and permeability-increasing inflammatory changes, which may related with the inflammation of psoriasis. IL-8 is a chemokine superfamily can induce chemotaxis of neutrophils to sites of inflammation, keratinocyte proliferation, enhanced vascular permeability induced angiogenesis, which participate in the pathogenesis of psoriasis. High levels of IL-8 in patients with psoriasis skin lesions and serum. Many methods to treat psoriasis, Chinese medicine as a treatment for psoriasis is indeed effective way to improve the condition and prolong remission, side effects,. The experiments with traditional Chinese medicine treatment of psoriasis, observe the traditional Chinese medicine Qingreliangxue eliminate mange soup, with compound qingdai pill control treatment blood heat vulgaris psoriasis; research Qingreliangxue Consumer mange soup unusual blood heat patients with psoriasis treatment serum levels of TNF-α, IL-8 level. Method: 1, clinical observations using randomized, controlled method, is divided into a treatment group (Qingreliangxue eliminate mange soup group) and control group (the compound qingdai pill group), 43 patients with psoriasis, for 8 weeks. Observed erythema, scaling, infiltration, systemic symptoms change in PASI scores before and after treatment, to evaluate the efficacy, at the same time observe the adverse reactions. 2, the experimental study using a double antibody sandwich enzyme-linked immunosorbent assay (ELISA) eliminate mange soup of Qingreliangxue before and after treatment, patients with psoriasis serum IL-8, TNF-α levels. Simultaneous determination of the above indicators of 10 healthy subjects. Results: The clinical observation: the treatment group of 23 patients in the control group of 20 cases. PASI score between the two groups before treatment, no significant difference (P> 0.05), comparable. Two groups PASI score after treatment than before treatment was significantly lower (P <0.05). The two groups overall effect was a significant difference (P <0.05). Experimental studies: A total of 26 cases, 16 cases of the treatment group and the normal control group of 10 patients. Serum TNF-α, IL-8, water on average higher than the normal control group, the difference was significant (P <0.05). Serum levels of TNF-α, IL-8 levels after treatment was significantly reduced, the difference was significant (P <0.05). Conclusion: Qingreliangxue exact eliminate mange soup treatment of psoriasis efficacy with in compound qingdai pill statistically significant difference (P <0.05). 2, a Consumer mange soup Qingreliangxue after treatment, serum levels of TNF-α, IL-8 levels improve as the disease reduced prompted Consumer mange soup Qingreliangxue may regulate TNF-α, IL-8 level. Its mechanism may play a therapeutic effect by regulating the immune and inflammatory response.
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