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Improved Synthesis Route of Ki16425 and the Study of Its Process

Author: CaiXiaYan
Tutor: CaiLiangZhen；ZhangHao
School: East China University of Science and Technology
Course: Pharmaceutical Engineering
Keywords: LPA inhibitor Kil6425 synthesize
CLC: TQ460.6
Type: Master's thesis
Year: 2011
Downloads: 42
Quote: 0
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Abstract


Ki16425, which is one of LPA inhibitor, was synthesized in our previous work based on the patent. H(?)cr, it was found that some steps could not be repeated and controlled. The total yield wa(?)ly 4.78%, which led to the difficulty of industrial production.The wor(?)scribed in this thesis utilised 1-iodo-chlorobenzene as starting materials to synthesize the target compound (Ki16425) via acetylation, reduction, cycliztion, hydrolyzatiorn and rearrangment, etc. All of compounds were characterized by LC-MS and H-NMR. Some uncontrolled steps were explored. The results showed that the yield was increased to 14.9% and the new syntheis route could be operated easily, which are suitable for industry.

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CLC: > Industrial Technology > Chemical Industry > Pharmaceutical chemical industry > General issues > Pharmaceutical Process
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