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Copper-Catalyzed Synthesis of Propargylamine and Quinazolinones

Author: ZhangQiang
Tutor: SuWeiKe；WuHuaYue
School: Wenzhou University
Course: Organic Chemistry
Keywords: Copper-catalyzed PEG-400 propargylamine derivatives quinazolinone derivatives
CLC: TQ252
Type: Master's thesis
Year: 2011
Downloads: 85
Quote: 0
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Abstract


Propargylamine and quinazolinone derivatives are very important intermediates in organic synthesis and pharmaceutical synthesis. With the guideline of green synthesis, this thesis investigated copper-catalyzed synthesis of propargylamine and quinazolinone derivatives in PEG-400. The thesis inculding two reactions were as followed: (1) CuI-catalyzed one-pot synthesis of propargylamines from three-component A3 coupling reaction of aldehyde, amine and alkyne in PEG-400; (2) A green, rapid, and efficient method was developed for synthesizing quinazolinone derivatives from substituted 2-halobenzoic acids and amidines via nano CuO-catalyzed cyclization in PEG-400.The important features of the methodology for quinoxalines and pyrazines are simple operation, mild reaction conditions and high yields. Moreover, reusable catalyst and solvent make the methods more economical and environmental friendly.

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