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The first part of the radionuclide the balance method blood pool imaging and echocardiography evaluation of left ventricular function Objective: To analyze the balance method of radionuclide blood pool imaging nuclide (hereinafter referred to as the Act) and echocardiography (hereinafter referred to as echocardiography method) Determination of left ventricular systolic and diastolic function parameters differences and correlation. Methods: 22 patients with no cardiovascular disease in patients whose tumors (untreated group) and 20 healthy volunteers (normal group) for a total of 42 cases in two days to accept the the radionuclide method checks and echocardiographic law examination. Independent sample t-test was used to compare the cardiac function between the two groups, paired t-test was used to compare the two methods. Results: 42 patients with radionuclide law and echocardiographic determination of left ventricular ejection fraction (LVEF) the difference was not statistically significant. Packet analysis of the untreated group and the normal group with two methods LVEF, the differences were not statistically significant. Radionuclide method imaging and echocardiographic determination of left ventricular ejection fraction (LVEF) was a good correlation, r = 0.678, P lt; 0.01. Normal group and the untreated group, the two methods LVEF still good correlation, r = 0.642 and 0.646, P lt; 0.01. The low radionuclide LVEF values ??measured by echocardiography average low (2.61 ± 4.45)%, P lt; 0.01. Tumor group nuclides measured LVEF compared with echocardiography method average (2.81 ± 4.06)%, P lt; 0.01, the normal group the radionuclide method measured LVEF compared with echocardiography method average (2.40 ± 4.94)%, P lt; 0.05. Analysis of diastolic function parameters measured by color Doppler mitral diastolic early / late blood flow velocity ratio (E / A) and tissue Doppler imaging (TDI), mitral valve ring the diastolic early / late tissue motion velocity ratio (Ea / Aa) were positively correlated (r = 0.802, P lt; 0.01). Radionuclide method for the determination of the peak filling rate (PFR) and echocardiography TDI measured Ea / Aa was a positive correlation r = 0.530, P lt; 0.01. Normal group radionuclide determination Ea / Aa of PFR heart ultra TDI measured correlation is still significant P lt; 0.05, but no correlation between the tumor group in both. Conclusion: The treatment of tumor patients before heart function consistent with the normal population. The radionuclide Determination LVEF heart than the ultra-low, but the consistency of the two is better. Determination of diastolic function, radionuclide method and echocardiographic method may not be able to replace each other. Left ventricular function after the purpose of the second part of the balance method of radionuclide blood pool imaging evaluation of patients with breast cancer treatment: damage to the heart function in patients with breast cancer after treatment will affect the patient's prognosis, treatment plan and treatment further implementation, this study aims to explore the impact of age, disease, different treatment of cardiac function in patients with breast cancer, the analysis may cause heart damage in patients with risk factors. Methods: A retrospective analysis of 106 patients with breast cancer radionuclide blood pool inspection results, treatment options: accept within one year prior to the statistical patient examination, 27 cases chemotherapy the CEF program of 28 cases, T programs 29 cases, CEF-T program; radiotherapy 22 cases; endocrine treatment of 30 cases; targeting the treatment of 43 cases. Multi-factor analysis of variance to age, stage of disease, the site of disease, the relationship of the various treatment and cardiac function indicators, group analysis of variance of different chemotherapy regimens on cardiac function, independent sample t-test was used to compare the left and right side of the chest wall radiotherapy after local ejection fraction difference. Results: different chemotherapy regimens affect left ventricular ejection fraction (LVEF), peak ejection rate (PER), peak filling rate (PFR), 1/3 ejection fraction (1/3EF) independent factors, Wald values ??were 0.466,0.431,0.360,0.280 (P lt; 0.05). Lesion site and radiotherapy factors affect LVEF and PFR interaction (P lt; 0.05). : CEF, T, CEF-T program and untreated patients with LVEF, PER, and PFR, 1/3EF differences were statistically significant (P lt; 0.05); CEF regimen compared different chemotherapy regimens cardiac function index twenty-two patients with LVEF, PER, PFR reduced compared with the other two chemotherapy regimens, the difference was statistically significant (P lt; 0.01), but the difference was not statistically significant parameters of heart function between T program and CEF-T program. In terms of what kind of chemotherapy after local ejection fraction of the left breast after radiotherapy sidewall below the right side of radiotherapy after local ejection fraction of the right side of the interventricular septum after radiotherapy below the left side of radiotherapy (P lt; 0.05). CEF or CEF-T regimen, the left side of the chest wall radiotherapy LVEF, PFR below the right side (P lt; 0.05). Conclusion: different chemotherapy regimens is independent factors affect heart function. The anthracycline epirubicin can still affect the patient's heart systolic and diastolic function, affect the extent of drug dose. No matter what kind of chemotherapy, increased breast radiotherapy can cause changes in local cardiac ejection fraction, the corresponding area of ??the the local reduced ejection fraction and heart by-ray irradiation. Radionuclide blood pool imaging can be used to monitor chemotherapy and radiotherapy in patients with cardiac function after change. The purpose of the third part of the radionuclide balance method blood pool imaging evaluation of left ventricular function in breast cancer patients with targeted therapy: targeted cancer therapy in breast cancer clinical applications to improve the prognosis of patients, but will affect the treatment of cardiac damage , clinical attention to the effective monitoring of cardiac function. In this study, clinical Taxol and lapatinib treatment of breast cancer patients were prospectively studied, observed a new type of breast cancer targeted therapy on cardiac function. Methods: 60 patients with breast cancer, according to the different treatment options A, B groups, A group of Taxol Jia Lapa imatinib program, a total of 25 cases; B group lapatinib Niger single-drug program, a total of 35 cases. Patients before treatment January, six months of medication and medication 12 months after the balance method blood pool imaging. The observed indicators include LVEF, PER, PFR, 1/3EF, 1/3FF, TPER and TPFR. The same group were compared using analysis of variance and paired t-test, independent samples t-test between the different groups. The results: A group of patients with medication were followed up after 6 months and 12 months to 24 cases and 16 cases of group B follow-up to the 34 cases and 28 cases respectively. Various indicators no significant difference between the two groups of patients before treatment. Group A after 6 months of treatment the PER and treatment before the difference was not statistically significant decline after 12 months of treatment, the difference was statistically significant (3.64 ± 0.68,12 months before treatment, 3.10 ± 0.40; P lt ; 0.05); A treatment after six months and 12 months respectively compared with before treatment, PFR decreases were statistically significant (3.11 ± 0.84,12 3.61 ± 1.02,6 months months before treatment, 2.79 ± 0.64 ; P lt; 0.05) in group A the remaining indicators before and after treatment the difference was not statistically significant. Group B, after 12 months of treatment, PFR was lower than before treatment was statistically significant (3.23 ± 0.87,12 months before treatment, 2.86 ± 0.55, P lt; 0.05), various indicators before and after treatment were not statistically significant. Conclusion: lapatinib Nepal combined with taxol or Rapa behalf of Nicaragua single-drug regimen can cause changes in cardiac function, which lapatinib Nepal combined with taxol program can cause cardiac function parameters PER, PFR decreased diastolic function as early as in contractile function. The lapatinib Niger single drug use can cause a decline in diastolic function. Lapatinib Nepal combined with taxol on cardiac function Bila Pa behalf Niger single drug appeared earlier, a greater degree of diastolic dysfunction. Various indexes PER, PFR reflect the changes in heart function than LVEF more sensitive. Radionuclide blood pool imaging can effectively monitor changes in cardiac function in patients with breast cancer targeted therapy.
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